Health Technology/clinical-trials

Novel PET/CT Imaging Model Aims to Predict Interstitial Lung Disease in Dermatomyositis Patients — Chinese Study Offers New Diagnostic Insights

247 Health News Editorial

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17 Apr 2026

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3 min read

·clinical-trials

Chinese researchers are developing a novel PET/CT imaging model combining 68Ga-FAPI and 18F-FDG tracers to predict interstitial lung disease in dermatomyositis patients. This innovative approach could transform early detection and risk stratification for this life-threatening complication.

Originally reported by ClinicalTrials.gov

References

  1. 1.Ruijin Hospital. (2024). Construction of a Clinico-Imaging Collaborative Diagnostic Model for Dermatomyositis Combined With Interstitial Lung Disease Based on PET/CT Imaging Features and Clinical Parameters. ClinicalTrials.gov. NCT07531446. https://clinicaltrials.gov/study/NCT07531446
  2. 2.Giesel, F. L., Kratochwil, C., Lindner, T., Marschalek, M. M., Loktev, A., Lehnert, W., Neels, O., Massoth, C., Woody, C., Hieulle, J., Staudinger, F., Wefers, A. K., Aulakh, S., Zechmann, C. M., Bensch, F., Schubert, K., Sohn, C., Alonso, O., Freudlsperger, C., ... Haberkorn, U. (2019). 68Ga-FAPI PET/CT: Biodistribution and preliminary dosimetry estimate of 2 FAPI tracers in patients with various cancers. Journal of Nuclear Medicine, 60(3), 386-392. https://doi.org/10.2967/jnumed.118.223024
  3. 3.Fujisawa, T., Hozumi, H., Kono, M., Enomoto, N., Hashimoto, D., Nakamura, Y., Inui, N., & Suda, T. (2021). Prognostic factors for myositis-associated interstitial lung disease. PLoS One, 16(1), e0245013. https://doi.org/10.1371/journal.pone.0245013
  4. 4.Lambin, P., Rios-Velazquez, E., Leijenaar, R., Carvalho, S., Van Stiphout, R. G., Granton, P., Zegers, C. M., Gillies, R., Boellard, R., Dekker, A., & Aerts, H. J. (2012). Radiomics: extracting more information from medical images using advanced feature analysis. European Journal of Cancer, 48(4), 441-446. https://doi.org/10.1016/j.ejca.2011.11.036
  5. 5.Bohan, A., & Peter, J. B. (1975). Polymyositis and dermatomyositis. New England Journal of Medicine, 292(7), 344-347. https://doi.org/10.1056/NEJM197502202920807
  6. 6.Travis, W. D., Costabel, U., Hansell, D. M., King Jr, T. E., Lynch, D. A., Nicholson, A. G., Ryerson, C. J., Ryu, J. H., Selman, M., Wells, A. U., Behr, J., Brown, K. K., Colby, T. V., Collard, H. R., Cordeiro, C. R., Cottin, V., Crestani, B., Drent, M., Dudden, R. F., ... Valeyre, D. (2013). An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. American Journal of Respiratory and Critical Care Medicine, 188(6), 733-748. https://doi.org/10.1164/rccm.201308-1483ST
  7. 7.Hallowell, R. W., Ascherman, D. P., & Danoff, S. K. (2014). Pulmonary manifestations of polymyositis/dermatomyositis. Seminars in Respiratory and Critical Care Medicine, 35(2), 239-248. https://doi.org/10.1055/s-0034-1376862
  8. 8.Connors, G. R., Christopher-Stine, L., Oddis, C. V., & Danoff, S. K. (2010). Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years? Chest, 138(6), 1464-1474. https://doi.org/10.1378/chest.09-2492
  9. 9.Kratochwil, C., Flechsig, P., Lindner, T., Abderrahim, L., Altmann, A., Mier, W., Adeberg, S., Rathke, H., Röhrich, M., Winter, H., Plinkert, P. K., Marme, F., Lang, M., Kauczor, H. U., Jäger, D., Debus, J., Haberkorn, U., & Giesel, F. L. (2019). 68Ga-FAPI PET/CT: tracer uptake in 28 different kinds of cancer. Journal of Nuclear Medicine, 60(6), 801-805. https://doi.org/10.2967/jnumed.119.227967
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