Novel Neuroimaging Trial Decodes Emotional Brain Dynamics in Bipolar Disorder — Implications for Precision Psychiatry
247 Health News Editorial
·20 Apr 2026
·4 min read
·clinical-trialsA groundbreaking neuroimaging study is using fMRI and machine learning to decode emotional brain dynamics in bipolar disorder. The research could identify biomarkers for mood instability and inform precision psychiatry approaches.
Originally reported by ClinicalTrials.gov
References
- 1.Deco, G., Kringelbach, M. L., Jirsa, V. K., & Ritter, P. (2017). The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core. Scientific Reports, 7(1), 3095. https://doi.org/10.1038/s41598-017-03073-5
- 2.Fernandes, B. S., Williams, L. M., Steiner, J., Leboyer, M., Carvalho, A. F., & Berk, M. (2017). The new field of 'precision psychiatry'. BMC Medicine, 15(1), 80. https://doi.org/10.1186/s12916-017-0849-x
- 3.Laureate Institute for Brain Research. (2024). Decoding emotional dynamics driving mood instability in bipolar disorder. ClinicalTrials.gov. NCT07221864. https://clinicaltrials.gov/study/NCT07221864
- 4.Merikangas, K. R., Jin, R., He, J. P., Kessler, R. C., Lee, S., Sampson, N. A., Viana, M. C., Andrade, L. H., Hu, C., Karam, E. G., Ladea, M., Medina-Mora, M. E., Ono, Y., Posada-Villa, J., Sagar, R., Wells, J. E., & Zarkov, Z. (2011). Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Archives of General Psychiatry, 68(3), 241-251. https://doi.org/10.1001/archgenpsychiatry.2011.12
- 5.Montgomery, S. A., & Åsberg, M. (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134(4), 382-389. https://doi.org/10.1192/bjp.134.4.382
- 6.Phillips, M. L., & Kupfer, D. J. (2013). Bipolar disorder diagnosis: challenges and future directions. The Lancet, 381(9878), 1663-1671. https://doi.org/10.1016/S0140-6736(13)60989-7
- 7.Strakowski, S. M., Adler, C. M., Almeida, J., Altshuler, L. L., Blumberg, H. P., Chang, K. D., DelBello, M. P., Frangou, S., McIntosh, A., Phillips, M. L., Sussman, J. E., & Townsend, J. D. (2012). The functional neuroanatomy of bipolar disorder: a consensus model. Bipolar Disorders, 14(4), 313-325. https://doi.org/10.1111/j.1399-5618.2012.01022.x
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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