Health Technology/clinical-trials

Novel Digital Biomarker Trial: Voice Analysis to Detect CAR-T Neurotoxicity in Haematological Malignancies

247 Health News Editorial

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17 Apr 2026

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3 min read

·clinical-trials

Memorial Sloan Kettering launches groundbreaking feasibility study using voice recordings as digital biomarkers to detect neurotoxicity in CAR-T cell therapy patients. The trial explores whether smartphone-based voice analysis can identify early signs of ICANS before clinical symptoms appear.

Originally reported by ClinicalTrials.gov

References

  1. 1.Memorial Sloan Kettering Cancer Center. (2024). Voice as a Digital Biomarker of Neurotoxicity in CAR T-Cell Therapy. ClinicalTrials.gov. NCT07249528. https://clinicaltrials.gov/study/NCT07249528
  2. 2.Santomasso, B. D., Park, J. H., Salloum, D., Riviere, I., Flynn, J., Mead, E., Halton, E., Wang, X., Senechal, B., Purdon, T., Heller, G., Zheng, J., Solit, D., Brentjens, R. J., Sauter, C. S., Sadelain, M., & Brentjens, R. J. (2018). Clinical and biological correlates of neurotoxicity associated with CAR T-cell therapy in patients with B-cell acute lymphoblastic leukemia. Cancer Discovery, 8(8), 958-971. https://doi.org/10.1158/2159-8290.CD-17-1319
  3. 3.Gust, J., Hay, K. A., Hanafi, L. A., Li, D., Myerson, D., Gonzalez-Cuyar, L. F., Yeung, C., Liles, W. C., Wurfel, M., Lopez, J. A., Chen, J., Chung, D., Harju-Baker, S., Özpolat, T., Fink, K. R., Riddell, S. R., Maloney, D. G., & Turtle, C. J. (2017). Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells. Cancer Discovery, 7(12), 1404-1419. https://doi.org/10.1158/2159-8290.CD-17-0698
  4. 4.Jacobson, C. A., Hunter, B. D., Redd, R., Rodig, S. J., Chen, P. H., Wright, K., Lipschitz, M., Ritz, J., Kamihara, Y., Armand, P., Roemer, M. G. M., Chapuy, B., Shipp, M. A., & Crombie, J. L. (2020). Axicabtagene ciloleucel in the non-trial setting: outcomes and correlates of response, resistance, and toxicity. Journal of Clinical Oncology, 38(15), 1651-1662. https://doi.org/10.1200/JCO.19.02103
  5. 5.Lee, D. W., Santomasso, B. D., Locke, F. L., Ghobadi, A., Turtle, C. J., Brudno, J. N., Maus, M. V., Park, J. H., Mead, E., Pavletic, S., Go, W. Y., Eldjerou, L., Gardner, R. A., Frey, N., Curran, K. J., Peggs, K., Pasquini, M., DiPersio, J. F., van den Brink, M. R. M., ... Neelapu, S. S. (2019). ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells. Biology of Blood and Marrow Transplantation, 25(4), 625-638. https://doi.org/10.1016/j.bbmt.2018.12.758
  6. 6.Fagherazzi, G., Fischer, A., Ismael, M., & Despotovic, V. (2021). Voice for health: the use of vocal biomarkers from research to clinical practice. Digital Medicine, 4(1), 30. https://doi.org/10.1038/s41746-021-00394-6
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