Novel Digital Biomarker Trial: Voice Analysis to Detect CAR-T Neurotoxicity in Haematological Malignancies
247 Health News Editorial
·17 Apr 2026
·3 min read
·clinical-trialsMemorial Sloan Kettering launches groundbreaking feasibility study using voice recordings as digital biomarkers to detect neurotoxicity in CAR-T cell therapy patients. The trial explores whether smartphone-based voice analysis can identify early signs of ICANS before clinical symptoms appear.
Originally reported by ClinicalTrials.gov
References
- 1.Memorial Sloan Kettering Cancer Center. (2024). Voice as a Digital Biomarker of Neurotoxicity in CAR T-Cell Therapy. ClinicalTrials.gov. NCT07249528. https://clinicaltrials.gov/study/NCT07249528
- 2.Santomasso, B. D., Park, J. H., Salloum, D., Riviere, I., Flynn, J., Mead, E., Halton, E., Wang, X., Senechal, B., Purdon, T., Heller, G., Zheng, J., Solit, D., Brentjens, R. J., Sauter, C. S., Sadelain, M., & Brentjens, R. J. (2018). Clinical and biological correlates of neurotoxicity associated with CAR T-cell therapy in patients with B-cell acute lymphoblastic leukemia. Cancer Discovery, 8(8), 958-971. https://doi.org/10.1158/2159-8290.CD-17-1319
- 3.Gust, J., Hay, K. A., Hanafi, L. A., Li, D., Myerson, D., Gonzalez-Cuyar, L. F., Yeung, C., Liles, W. C., Wurfel, M., Lopez, J. A., Chen, J., Chung, D., Harju-Baker, S., Özpolat, T., Fink, K. R., Riddell, S. R., Maloney, D. G., & Turtle, C. J. (2017). Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells. Cancer Discovery, 7(12), 1404-1419. https://doi.org/10.1158/2159-8290.CD-17-0698
- 4.Jacobson, C. A., Hunter, B. D., Redd, R., Rodig, S. J., Chen, P. H., Wright, K., Lipschitz, M., Ritz, J., Kamihara, Y., Armand, P., Roemer, M. G. M., Chapuy, B., Shipp, M. A., & Crombie, J. L. (2020). Axicabtagene ciloleucel in the non-trial setting: outcomes and correlates of response, resistance, and toxicity. Journal of Clinical Oncology, 38(15), 1651-1662. https://doi.org/10.1200/JCO.19.02103
- 5.Lee, D. W., Santomasso, B. D., Locke, F. L., Ghobadi, A., Turtle, C. J., Brudno, J. N., Maus, M. V., Park, J. H., Mead, E., Pavletic, S., Go, W. Y., Eldjerou, L., Gardner, R. A., Frey, N., Curran, K. J., Peggs, K., Pasquini, M., DiPersio, J. F., van den Brink, M. R. M., ... Neelapu, S. S. (2019). ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells. Biology of Blood and Marrow Transplantation, 25(4), 625-638. https://doi.org/10.1016/j.bbmt.2018.12.758
- 6.Fagherazzi, G., Fischer, A., Ismael, M., & Despotovic, V. (2021). Voice for health: the use of vocal biomarkers from research to clinical practice. Digital Medicine, 4(1), 30. https://doi.org/10.1038/s41746-021-00394-6
2
247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
Related Articles
clinical-trials
Digital Health Platform vs Case Manager Support in Hypertension Management: Taiwan's 1,726-Participant Trial Signals a Shift in Blood Pressure Care Delivery
3 Aug 2026
clinical-trials
Phase II Trial: AI-Powered Wysa Chatbot vs Unmet Need — Digital Eating Disorder Prevention in At-Risk Adolescents
3 Aug 2026
clinical-trials
Pilot Trial Targets the Inpatient-to-Outpatient Gap: Digital Smoking Cessation Intervention for Persons With Serious Mental Illness — Key Findings for Clinicians
3 Aug 2026
This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service