NEXAF Trial Complete: eHealth-Guided Exercise vs Usual Care in Atrial Fibrillation — Implications for Cardiac Rehabilitation Practice
247 Health News Editorial
·27 July 2026
·5 min read
·clinical-trialsThe completed NEXAF trial — a 300-participant Norwegian multicentre RCT — has tested whether a 12-month eHealth-delivered home exercise programme can reduce AF burden and improve quality of life in patients with paroxysmal or persistent atrial fibrillation. Using continuous cardiac rhythm monitoring as an objective endpoint, NEXAF is poised to deliver the most rigorous evidence yet for exercise prescriptions in AF management.
Originally reported by ClinicalTrials.gov
References
- 1.Norwegian University of Science and Technology. (2022). The Norwegian Exercise in Atrial Fibrillation Trial (NEXAF): An open-label, multicenter randomized controlled trial comparing an eHealth-based exercise intervention with usual care after 12 months follow-up. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05164718
- 2.Lippi, G., Sanchis-Gomar, F., & Cervellin, G. (2021). Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. International Journal of Stroke, 16(2), 217–221. https://doi.org/10.1177/1747493019897870
- 3.Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström-Lundqvist, C., Boriani, G., Castella, M., Dan, G. A., Dilaveris, P. E., Fauchier, L., Filippatos, G., Kalman, J. M., La Meir, M., Lane, D. A., Lebeau, J. P., Lettino, M., Lip, G. Y. H., Pinto, F. J., … ESC Scientific Document Group. (2021). 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). European Heart Journal, 42(5), 373–498. https://doi.org/10.1093/eurheartj/ehaa612
- 4.Chew, D. P., Scott, I. A., Cullen, L., French, J. K., Briffa, T. G., Tideman, P. A., Woodruffe, S., Kerr, A., Branagan, M., & Aylward, P. E. G. (2016). National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes 2016. Heart, Lung and Circulation, 25(9), 895–951. https://doi.org/10.1016/j.hlc.2016.06.789
- 5.Malmo, V., Nes, B. M., Amundsen, B. H., Tjonna, A. E., Stoylen, A., Rossvoll, O., Wisloff, U., & Loennechen, J. P. (2016). Aerobic interval training reduces the burden of atrial fibrillation in the short term: A randomized trial. Circulation, 133(5), 466–473. https://doi.org/10.1161/CIRCULATIONAHA.115.018220
- 6.Buckley, B. J. R., Lip, G. Y. H., & Thijssen, D. H. J. (2021). The counterintuitive role of exercise in the prevention and cause of atrial fibrillation. American Journal of Physiology — Heart and Circulatory Physiology, 320(4), H1051–H1067. https://doi.org/10.1152/ajpheart.00416.2020
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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