Health Technology/clinical-trials

NCI Opens Wearable Temperature Monitoring Trial to Prevent Severe Cytokine Release Syndrome in Cancer Immunotherapy

247 Health News Editorial

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4 Apr 2026

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4 min read

·clinical-trials

The National Cancer Institute launches a trial investigating continuous temperature monitoring to prevent severe cytokine release syndrome in cancer immunotherapy patients. The study examines whether wearable TempTraq patches can detect fever patterns earlier than standard monitoring, potentially reducing life-threatening CRS complications.

Originally reported by ClinicalTrials.gov

References

  1. 1.National Cancer Institute. (2024). Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse Event. ClinicalTrials.gov. NCT07499128. https://clinicaltrials.gov/study/NCT07499128
  2. 2.Shimabukuro-Vornhagen, A., Gödel, P., Subklewe, M., Stemmler, H. J., Schlößer, H. A., Schlaak, M., Kochanek, M., Böll, B., & von Bergwelt-Baildon, M. (2018). Cytokine release syndrome. Journal for ImmunoTherapy of Cancer, 6(1), 56. https://doi.org/10.1186/s40425-018-0343-9
  3. 3.Lee, D. W., Santomasso, B. D., Locke, F. L., Ghobadi, A., Turtle, C. J., Brudno, J. N., Maus, M. V., Park, J. H., Mead, E., Pavletic, S., Go, W. Y., Eldjerou, L., Gardner, R. A., Frey, N., Curran, K. J., Maloney, D. G., Hicks, C., Pasquini, M., Appelbaum, F. R., ... Neelapu, S. S. (2019). ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells. Biology of Blood and Marrow Transplantation, 25(4), 625-638. https://doi.org/10.1016/j.bbmt.2018.12.758
  4. 4.Neelapu, S. S., Tummala, S., Kebriaei, P., Wierda, W., Gutierrez, C., Locke, F. L., Komanduri, K. V., Lin, Y., Jain, N., Daver, N., Westin, J., Gulbis, A. M., Loghin, M. E., de Groot, J. F., Adkins, S., Davis, S. E., Rezvani, K., Hwu, P., & Shpall, E. J. (2018). Chimeric antigen receptor T-cell therapy—assessment and management of toxicities. Nature Reviews Clinical Oncology, 15(1), 47-62. https://doi.org/10.1038/nrclinonc.2017.148
  5. 5.Maude, S. L., Barrett, D., Teachey, D. T., & Grupp, S. A. (2014). Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer Journal, 20(2), 119-122. https://doi.org/10.1097/PPO.0000000000000035
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