Multicentre Study Evaluates AI-Enhanced Imaging for Prostate Cancer Risk Stratification — Potential to Reduce Unnecessary Biopsies
247 Health News Editorial
·14 June 2026
·3 min read
·clinical-trialsA large multicentre study is evaluating whether deep learning models combining MRI, ultrasound, and digital pathology can improve prostate cancer risk stratification and reduce unnecessary biopsies. The 3,000-patient study aims to validate AI-enhanced imaging for more accurate diagnosis of clinically significant prostate cancer.
Originally reported by ClinicalTrials.gov
References
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- 2.Greer, M. D., Brown, A. M., Shih, J. H., Summers, R. M., Marko, J., Law, Y. M., ... & Turkbey, B. (2017). Accuracy and agreement of PIRADSv2 for prostate cancer mpMRI: a multireader study. Journal of Magnetic Resonance Imaging, 45(3), 579-585. https://doi.org/10.1002/jmri.25645
- 3.Guangxi Medical University. (2024). A Multicenter Study of a Deep Learning Model Based on Spatial Registration of Multimodal Imaging and Digital Pathology for Predicting Clinically Significant Prostate Cancer. ClinicalTrials.gov. NCT07614256. https://clinicaltrials.gov/study/NCT07614256
- 4.Kasivisvanathan, V., Rannikko, A. S., Borghi, M., Panebianco, V., Mynderse, L. A., Vaarala, M. H., ... & Moore, C. M. (2018). MRI-targeted or standard biopsy for prostate-cancer diagnosis. New England Journal of Medicine, 378(19), 1767-1777. https://doi.org/10.1056/NEJMoa1801993
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- 6.Loeb, S., Bjurlin, M. A., Nicholson, J., Tammela, T. L., Penson, D. F., Carter, H. B., ... & Etzioni, R. (2014). Overdiagnosis and overtreatment of prostate cancer. European Urology, 65(6), 1046-1055. https://doi.org/10.1016/j.eururo.2014.01.036
- 7.Loeb, S., Carter, H. B., Berndt, S. I., Ricker, W., & Schaeffer, E. M. (2011). Complications after prostate biopsy: data from SEER-Medicare. Journal of Urology, 186(5), 1830-1834. https://doi.org/10.1016/j.juro.2011.05.074
- 8.National Health and Medical Research Council. (2023). National Statement on Ethical Conduct in Human Research. NHMRC. https://www.nhmrc.gov.au/about-us/publications/national-statement-ethical-conduct-human-research-2023
- 9.Weinreb, J. C., Barentsz, J. O., Choyke, P. L., Cornud, F., Haider, M. A., Macura, K. J., ... & Verma, S. (2016). PI-RADS Prostate Imaging–Reporting and Data System: 2015, version 2. European Urology, 69(1), 16-40. https://doi.org/10.1016/j.eururo.2015.08.052
- 10.Welch, H. G., & Black, W. C. (2010). Overdiagnosis in cancer. Journal of the National Cancer Institute, 102(9), 605-613. https://doi.org/10.1093/jnci/djq099
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247 Health News Editorial
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