Multicenter Validation Trial Opens: Novel APTTO Model Uses Clot Waveform Analysis to Predict Pathological Causes of Prolonged APTT — What Haematologists Need to Know
247 Health News Editorial
·9 May 2026
·4 min read
·clinical-trialsSpanish researchers are validating the APTTO predictive model, which uses clot waveform analysis to differentiate pathological from benign causes of prolonged APTT. This 1,500-patient multicenter study could revolutionize coagulation diagnostics by providing immediate risk stratification using routine laboratory data.
Originally reported by ClinicalTrials.gov
References
- 1.Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz. (2024). Multicenter External Validation of the APTTO Predictive Model Based on Clot Waveform Analysis for the Assessment of Prolonged Activated Partial Thromboplastin Time. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07418099
- 2.Favaloro, E. J., & Lippi, G. (2023). Lupus anticoagulant testing: current perspectives and future directions. Pathology, 55(3), 285-295. https://doi.org/10.1016/j.pathol.2023.02.008
- 3.Ninivaggi, M., Apitz-Castro, R., Dargaud, Y., de Laat, B., Hemker, H. C., & Lindhout, T. (2022). Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay. Clinical Chemistry, 68(10), 1282-1291. https://doi.org/10.1093/clinchem/hvac142
- 4.Rodríguez-González, R., Páez-Guillán, P., & García-González, X. (2023). Clot waveform analysis: a new tool for hemostasis monitoring. International Journal of Laboratory Hematology, 45(4), 512-520. https://doi.org/10.1111/ijlh.14021
- 5.Collins, G. S., Reitsma, J. B., Altman, D. G., & Moons, K. G. (2015). Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. BMJ, 350, g7594. https://doi.org/10.1136/bmj.g7594
- 6.Adcock, D. M., Kressin, D. C., & Marlar, R. A. (2021). The effect of time and temperature variables on routine coagulation tests. Blood Coagulation & Fibrinolysis, 32(4), 256-263. https://doi.org/10.1097/MBC.0000000000001031
- 7.Kitchen, S., McCraw, A., & Echenagucia, M. (2020). Diagnosis of hemophilia and other bleeding disorders: a laboratory manual. World Federation of Hemophilia. https://www1.wfh.org/publications/files/pdf-1575.pdf
- 8.Favaloro, E. J. (2022). Von Willebrand disease: local diagnosis and management of a globally distributed bleeding disorder. Seminars in Thrombosis and Hemostasis, 48(7), 784-808. https://doi.org/10.1055/s-0042-1756306
2
247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
Related Articles
clinical-trials
Digital Health Platform vs Case Manager Support in Hypertension Management: Taiwan's 1,726-Participant Trial Signals a Shift in Blood Pressure Care Delivery
3 Aug 2026
clinical-trials
Phase II Trial: AI-Powered Wysa Chatbot vs Unmet Need — Digital Eating Disorder Prevention in At-Risk Adolescents
3 Aug 2026
clinical-trials
Pilot Trial Targets the Inpatient-to-Outpatient Gap: Digital Smoking Cessation Intervention for Persons With Serious Mental Illness — Key Findings for Clinicians
3 Aug 2026
This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service