Health Technology/clinical-trials

Multi-Centre Trial Evaluates Digital Screening Tools vs Clinical Assessment for Periodontal Disease Detection — 2,000 Patient Study

247 Health News Editorial

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5 May 2026

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4 min read

·clinical-trials

International diagnostic accuracy study evaluates digital screening tools including imaging, biomarkers, and questionnaires against clinical examination for detecting periodontal disease. 2,000 participants across multiple centres will validate non-invasive screening approaches.

Originally reported by ClinicalTrials.gov

References

  1. 1.Australian Institute of Health and Welfare. (2020). Oral health and dental care in Australia (AIHW-DEN-231). https://www.aihw.gov.au/reports/dental-oral-health/oral-health-and-dental-care-in-australia
  2. 2.Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L., Lijmer, J. G., Glas, A. S., Dowton, S. B., de Vet, H. C., & Cohen, J. F. (2015). STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ, 351, h5527. https://doi.org/10.1136/bmj.h5527
  3. 3.Caton, J. G., Armitage, G., Berglundh, T., Chapple, I. L., Jepsen, S., Kornman, K. S., Mealey, B. L., Papapanou, P. N., Sanz, M., & Tonetti, M. S. (2018). A new classification scheme for periodontal and peri‐implant diseases and conditions. Journal of Periodontology, 89(S1), S1-S8. https://doi.org/10.1002/JPER.18-0157
  4. 4.Kassebaum, N. J., Bernabé, E., Dahiya, M., Bhandari, B., Murray, C. J., & Marcenes, W. (2014). Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. Journal of Dental Research, 93(11), 1045-1053. https://doi.org/10.1177/0022034514552491
  5. 5.Krois, J., Ekert, T., Meinhold, L., Golla, T., Kharbot, B., Wittemeier, A., Dörfer, C., & Schwendicke, F. (2019). Deep learning for the radiographic detection of periodontal bone loss. Scientific Reports, 9(1), 8495. https://doi.org/10.1038/s41598-019-44839-3
  6. 6.Sanz, M., Ceriello, A., Buysschaert, M., Chapple, I., Demmer, R. T., Graziani, F., Herrera, D., Jepsen, S., Lione, L., Madianos, P., Mathur, M., Montanya, E., Shapira, L., Tonetti, M., & Vegh, D. (2018). Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes. Journal of Clinical Periodontology, 45(2), 138-149. https://doi.org/10.1111/jcpe.12808
  7. 7.Shanghai Ninth People's Hospital. (2024). Diagnostic Accuracy of Oral Images, Orthopantomographs (OPGs), Biomarkers and Self-Reported Questionnaires vs. Clinical Assessment for Detecting Periodontal Health and Disease: a Multi-center Diagnostic Study. ClinicalTrials.gov. NCT07406867. https://clinicaltrials.gov/study/NCT07406867
  8. 8.Tonetti, M. S., Greenwell, H., & Kornman, K. S. (2018). Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. Journal of Periodontology, 89(S1), S159-S172. https://doi.org/10.1002/JPER.18-0006
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