Health Technology/clinical-trials

MOST Framework Trial Tests mHealth Physical Activity Components for Young Adult Cancer Survivors — Optimizing Digital Interventions

247 Health News Editorial

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11 June 2026

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4 min read

·clinical-trials

Northwestern University researchers are using advanced factorial design methodology to identify which specific components of digital health interventions most effectively increase physical activity in young adult cancer survivors. The MOST framework trial tests e-coaching, buddy support, and mindfulness training elements.

Originally reported by ClinicalTrials.gov

References

  1. 1.Northwestern University. (2024). Optimization of a mHealth Physical Activity Promotion Intervention With Mindful Awareness for Adolescent and Young Adult Cancer Survivors. ClinicalTrials.gov. NCT05375162. https://clinicaltrials.gov/study/NCT05375162
  2. 2.Collins, L. M., Dziak, J. J., Kugler, K. C., & Trail, J. B. (2014). Factorial experiments: efficient tools for evaluation of intervention components. American Journal of Preventive Medicine, 47(4), 498-504. https://doi.org/10.1016/j.amepre.2014.06.021
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  5. 5.Nahum-Shani, I., Smith, S. N., Spring, B. J., Collins, L. M., Witkiewitz, K., Tewari, A., & Murphy, S. A. (2018). Just-in-time adaptive interventions (JITAIs) in mobile health: key components and design principles for ongoing health behavior support. Annals of Behavioral Medicine, 52(6), 446-462. https://doi.org/10.1093/abm/kax020
  6. 6.Bellizzi, K. M., Rowland, J. H., Jeffery, D. D., & McNeel, T. (2005). Health behaviors of cancer survivors: examining opportunities for cancer control intervention. Journal of Clinical Oncology, 23(34), 8884-8893. https://doi.org/10.1200/JCO.2005.02.2343
  7. 7.Zebrack, B. J., Corbett, V., Embry, L., Aguilar, C., Meeske, K. A., Hayes-Lattin, B., & Cole, S. (2014). Psychological distress and unsatisfied need for psychosocial support in adolescent and young adult cancer patients during the first year following diagnosis. Psycho-Oncology, 23(12), 1267-1275. https://doi.org/10.1002/pon.3414
  8. 8.Rock, C. L., Doyle, C., Demark-Wahnefried, W., Meyerhardt, J., Courneya, K. S., Schwartz, A. L., & Gansler, T. (2012). Nutrition and physical activity guidelines for cancer survivors. CA: A Cancer Journal for Clinicians, 62(4), 243-274. https://doi.org/10.3322/caac.21142
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247 Health News Editorial

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