Health Technology/clinical-trials

Micro-Randomised Trial Tests AI-Powered Interventions for Dietary Adherence in Obesity Treatment — Novel JITAI Approach Shows Promise

247 Health News Editorial

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7 June 2026

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4 min read

·clinical-trials

A groundbreaking micro-randomised trial is testing smartphone-based just-in-time adaptive interventions to prevent dietary lapses in obesity treatment. The study uses machine learning to deliver personalised support precisely when patients are at highest risk of dietary non-adherence.

Originally reported by ClinicalTrials.gov

References

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  2. 2.Butryn, M. L., Webb, V., & Wadden, T. A. (2011). Behavioral treatment of obesity. Psychiatric Clinics of North America, 34(4), 841-859. https://doi.org/10.1016/j.psc.2011.02.008
  3. 3.Hekler, E. B., Klasnja, P., Riley, W. T., Buman, M. P., Huberty, J., Rivera, D. E., & Martin, C. A. (2016). Agile science: creating useful products for behavior change in the real world. Translational Behavioral Medicine, 6(2), 317-328. https://doi.org/10.1007/s13142-016-0395-7
  4. 4.Jensen, M. D., Ryan, D. H., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Donato, K. A., ... & Yanovski, S. Z. (2014). 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults. Journal of the American College of Cardiology, 63(25), 2985-3023. https://doi.org/10.1016/j.jacc.2013.11.004
  5. 5.Klasnja, P., Hekler, E. B., Shiffman, S., Boruvka, A., Almirall, D., Tewari, A., & Murphy, S. A. (2015). Microrandomized trials: An experimental design for developing just-in-time adaptive interventions. Health Psychology, 34(S), 1220-1228. https://doi.org/10.1037/hea0000305
  6. 6.Liao, P., Klasnja, P., Tewari, A., & Murphy, S. A. (2016). Sample size calculations for micro-randomized trials in mHealth. Statistics in Medicine, 35(12), 1944-1971. https://doi.org/10.1002/sim.6847
  7. 7.MacLellan, J., Moldovan-Johnson, M., Domoff, S. E., & Gow, R. W. (2016). Picky eating in adults: phenomenology, classification, and measurement. Food Quality and Preference, 48, 298-306. https://doi.org/10.1016/j.foodqual.2015.06.007
  8. 8.Nahum-Shani, I., Smith, S. N., Spring, B. J., Collins, L. M., Witkiewitz, K., Tewari, A., & Murphy, S. A. (2018). Just-in-time adaptive interventions (JITAIs) in mobile health: key components and design principles for ongoing health behavior support. Annals of Behavioral Medicine, 52(6), 446-462. https://doi.org/10.1093/abm/kax020
  9. 9.The Miriam Hospital. (2024). Optimizing Just-in-Time Adaptive Intervention to Improve Dietary Adherence in Behavioral Obesity Treatment: A Micro-randomized Trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT04784585
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