Health Technology/clinical-trials

MASAI Study Completed: AI-Enhanced Mammography Screening Shows Promise in 100,000-Woman Trial — Implications for Australian Breast Cancer Screening

247 Health News Editorial

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4 Apr 2026

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3 min read

·clinical-trials

The MASAI study, involving 100,000 women, has completed evaluation of AI-enhanced mammography screening versus conventional double reading. Results expected in early 2025 could reshape breast cancer screening protocols globally, including Australia's BreastScreen programs.

Originally reported by ClinicalTrials.gov

References

  1. 1.Australian Institute of Health and Welfare. (2024). BreastScreen Australia monitoring report 2024. AIHW. https://www.aihw.gov.au/reports/cancer-screening/breastscreen-australia-monitoring-report-2024
  2. 2.Burnside, E. S., Sickles, E. A., Bassett, L. W., Rubin, D. L., Lee, C. H., Ikeda, D. M., Mendelson, E. B., Wilcox, P. A., Butler, P. F., & D'Orsi, C. J. (2009). The ACR BI-RADS experience: learning from history. Journal of the American College of Radiology, 6(12), 851-860. https://doi.org/10.1016/j.jacr.2009.03.023
  3. 3.Department of Health and Aged Care. (2023). Medical Services Advisory Committee: Guidelines for the assessment of diagnostic technologies. Australian Government. https://www.health.gov.au/committees-and-groups/medical-services-advisory-committee-msac
  4. 4.Hofvind, S., Ponti, A., Patnick, J., Ascunce, N., Njor, S., Broeders, M., Giordano, L., Frigerio, A., Törnberg, S., Düffy, S., Lynge, E., & Olsen, A. H. (2012). False-positive results in mammographic screening for breast cancer in Europe: a literature review and survey of service screening programmes. Journal of Medical Screening, 19(2), 57-66. https://doi.org/10.1258/jms.2012.012083
  5. 5.Lång, K., Dustler, M., Dahlblom, V., Åkesson, A., Andersson, I., Zackrisson, S., & Tingberg, A. (2023). Identifying normal mammograms in a large screening population using artificial intelligence. European Radiology, 33(3), 1710-1717. https://doi.org/10.1007/s00330-022-09200-7
  6. 6.McKinney, S. M., Sieniek, M., Godbole, V., Godwin, J., Antropova, N., Ashrafian, H., Back, T., Chesus, M., Corrado, G. C., Darzi, A., Etemadi, M., Garcia-Vicente, F., Gilbert, F. J., Halling-Brown, M., Hassabis, D., Jansen, S., Karthikesalingam, A., Kelly, C. J., King, D., ... Shetty, S. (2020). International evaluation of an AI system for breast cancer screening. Nature, 577(7788), 89-94. https://doi.org/10.1038/s41586-019-1799-6
  7. 7.Region Skane. (2024). A Randomized, Single-blinded, Controlled Trial on the Efficacy of Mammography Screening With Artificial Intelligence - the MASAI Study. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT04838756
  8. 8.Salim, M., Wåhlin, E., Dembrower, K., Azavedo, E., Foukakis, T., Liu, Y., Smith, K., Eklund, M., & Strand, F. (2020). External evaluation of 3 commercial artificial intelligence algorithms for independent assessment of screening mammograms. JAMA Oncology, 6(10), 1581-1588. https://doi.org/10.1001/jamaoncol.2020.3321
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