Health Technology/clinical-trials

Major Trial Compares Sequential vs Single Digital CBT Approaches for Veterans with Co-occurring Insomnia and Depression

247 Health News Editorial

·

16 Apr 2026

·

3 min read

·clinical-trials

A groundbreaking 1,500-participant trial is comparing digital CBT approaches for veterans with co-occurring insomnia and depression. The study will determine optimal treatment sequencing and develop personalised intervention algorithms.

Originally reported by ClinicalTrials.gov

References

  1. 1.Australian Government Department of Health. (2023). Better Access to Psychiatrists, Psychologists and General Practitioners through the MBS. Australian Government. https://www.health.gov.au/our-work/better-access
  2. 2.Baglioni, C., Battagliese, G., Feige, B., & Spiegelhalder, K. (2011). Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. Journal of Affective Disorders, 135(1-3), 10-19. https://doi.org/10.1016/j.jad.2011.01.011
  3. 3.Bramoweth, A. D., & Taylor, D. J. (2012). Chronic insomnia and health care utilization in young adults. Behavioral Sleep Medicine, 10(2), 106-121. https://doi.org/10.1080/15402002.2011.557992
  4. 4.Freeman, D., Sheaves, B., Goodwin, G. M., & Yu, L. M. (2017). The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis. The Lancet Psychiatry, 4(10), 749-758. https://doi.org/10.1016/S2215-0366(17)30328-0
  5. 5.Gebara, M. A., Siripong, N., DiNapoli, E. A., & Maree, R. D. (2018). Effect of insomnia treatments on depression: A systematic review and meta-analysis. Depression and Anxiety, 35(8), 717-731. https://doi.org/10.1002/da.22776
  6. 6.Kroenke, K., Spitzer, R. L., & Williams, J. B. (2001). The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606-613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x
  7. 7.Manber, R., Buysse, D. J., Edinger, J., & Krystal, A. (2021). Efficacy of cognitive-behavioral therapy for insomnia combined with antidepressant pharmacotherapy in patients with comorbid depression and insomnia. JAMA Psychiatry, 78(4), 384-392. https://doi.org/10.1001/jamapsychiatry.2021.0177
  8. 8.Mysliwiec, V., Brock, M. S., Creamer, J. L., & O'Reilly, B. M. (2018). Trauma associated sleep disorder: a proposed parasomnia encompassing disruptive nocturnal behaviors. Sleep Medicine Reviews, 37, 94-111. https://doi.org/10.1016/j.smrv.2017.06.003
  9. 9.Pigeon, W. R., Bishop, T. M., & Krueger, K. M. (2017). Insomnia as a precipitating factor in new onset mental illness. Sleep Medicine Clinics, 12(3), 439-451. https://doi.org/10.1016/j.jsmc.2017.03.015
  10. 10.Ritterband, L. M., Thorndike, F. P., Ingersoll, K. S., & Lord, H. R. (2017). Effect of a web-based cognitive behavior therapy for insomnia intervention with 1-year follow-up. JAMA Psychiatry, 74(1), 68-75. https://doi.org/10.1001/jamapsychiatry.2017.0844
  11. 11.University of Rochester. (2022). Optimizing Digital Behavioral Treatment for Co-occurring Insomnia and Depression. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05456607
Share:XLinkedIn
2

247 Health News Editorial

247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.

This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service