Major Trial Compares Sequential vs Single Digital CBT Approaches for Veterans with Co-occurring Insomnia and Depression
247 Health News Editorial
·16 Apr 2026
·3 min read
·clinical-trialsA groundbreaking 1,500-participant trial is comparing digital CBT approaches for veterans with co-occurring insomnia and depression. The study will determine optimal treatment sequencing and develop personalised intervention algorithms.
Originally reported by ClinicalTrials.gov
References
- 1.Australian Government Department of Health. (2023). Better Access to Psychiatrists, Psychologists and General Practitioners through the MBS. Australian Government. https://www.health.gov.au/our-work/better-access
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- 3.Bramoweth, A. D., & Taylor, D. J. (2012). Chronic insomnia and health care utilization in young adults. Behavioral Sleep Medicine, 10(2), 106-121. https://doi.org/10.1080/15402002.2011.557992
- 4.Freeman, D., Sheaves, B., Goodwin, G. M., & Yu, L. M. (2017). The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis. The Lancet Psychiatry, 4(10), 749-758. https://doi.org/10.1016/S2215-0366(17)30328-0
- 5.Gebara, M. A., Siripong, N., DiNapoli, E. A., & Maree, R. D. (2018). Effect of insomnia treatments on depression: A systematic review and meta-analysis. Depression and Anxiety, 35(8), 717-731. https://doi.org/10.1002/da.22776
- 6.Kroenke, K., Spitzer, R. L., & Williams, J. B. (2001). The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606-613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x
- 7.Manber, R., Buysse, D. J., Edinger, J., & Krystal, A. (2021). Efficacy of cognitive-behavioral therapy for insomnia combined with antidepressant pharmacotherapy in patients with comorbid depression and insomnia. JAMA Psychiatry, 78(4), 384-392. https://doi.org/10.1001/jamapsychiatry.2021.0177
- 8.Mysliwiec, V., Brock, M. S., Creamer, J. L., & O'Reilly, B. M. (2018). Trauma associated sleep disorder: a proposed parasomnia encompassing disruptive nocturnal behaviors. Sleep Medicine Reviews, 37, 94-111. https://doi.org/10.1016/j.smrv.2017.06.003
- 9.Pigeon, W. R., Bishop, T. M., & Krueger, K. M. (2017). Insomnia as a precipitating factor in new onset mental illness. Sleep Medicine Clinics, 12(3), 439-451. https://doi.org/10.1016/j.jsmc.2017.03.015
- 10.Ritterband, L. M., Thorndike, F. P., Ingersoll, K. S., & Lord, H. R. (2017). Effect of a web-based cognitive behavior therapy for insomnia intervention with 1-year follow-up. JAMA Psychiatry, 74(1), 68-75. https://doi.org/10.1001/jamapsychiatry.2017.0844
- 11.University of Rochester. (2022). Optimizing Digital Behavioral Treatment for Co-occurring Insomnia and Depression. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05456607
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247 Health News Editorial
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