Major Deep Learning Study Validates ECG-Based Prediction of Heart Failure With Reduced Ejection Fraction — Clinical Implications for Early Detection
247 Health News Editorial
·10 Apr 2026
·3 min read
·clinical-trialsA major multinational study of 286,709 patients validates deep learning algorithms using standard 12-lead ECGs to predict heart failure with reduced ejection fraction up to 5 years before clinical onset. This breakthrough could transform cardiovascular prevention strategies using readily available diagnostic tools.
Originally reported by ClinicalTrials.gov
References
- 1.Attia, Z. I., Kapa, S., Lopez-Jimenez, F., McKie, P. M., Ladewig, D. J., Satam, G., ... & Friedman, P. A. (2019). Screening for cardiac contractile dysfunction using an artificial intelligence–enabled electrocardiogram. Nature Medicine, 25(1), 70-74. https://doi.org/10.1038/s41591-018-0240-2
- 2.Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., ... & Yancy, C. W. (2022). 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation, 145(18), e895-e1032. https://doi.org/10.1161/CIR.0000000000001063
- 3.Kwon, J. M., Kim, K. H., Medina-Inojosa, J., Jeon, K. H., Park, J., & Oh, B. H. (2019). Artificial intelligence for early prediction of pulmonary hypertension using electrocardiography. Journal of Heart and Lung Transplantation, 38(8), 847-856. https://doi.org/10.1016/j.healun.2019.04.007
- 4.Raghunath, S., Pfeifer, J. M., Ulloa-Cerna, A. E., Nemani, A., Carbonati, T., Jing, L., ... & Fornwalt, B. K. (2021). Deep neural networks can predict new-onset atrial fibrillation from the 12-lead ECG and help identify those at risk of atrial fibrillation-related stroke. Circulation, 143(13), 1287-1298. https://doi.org/10.1161/CIRCULATIONAHA.120.047829
- 5.Shanghai Zhongshan Hospital. (2024). Electrocardiogram-Based Deep Learning for Time-Resolved Prediction of Heart Failure With Reduced Ejection Fraction: A Multinational Study. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07519434
- 6.Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., ... & Tsao, C. W. (2021). Heart disease and stroke statistics—2021 update: a report from the American Heart Association. Circulation, 143(8), e254-e743. https://doi.org/10.1161/CIR.0000000000000950
- 7.Yao, X., McCoy, R. G., Friedman, P. A., Shah, N. D., Barry, B. A., Behnken, E. M., ... & Attia, Z. I. (2021). ECG AI-guided screening for low ejection fraction (EAGLE): rationale and design of a pragmatic cluster randomized trial. American Heart Journal, 239, 137-146. https://doi.org/10.1016/j.ahj.2021.04.016
- 8.Yusuf, S., Pitt, B., Davis, C. E., Hood, W. B., & Cohn, J. N. (1991). Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. New England Journal of Medicine, 325(5), 293-302. https://doi.org/10.1056/NEJM199108013250501
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247 Health News Editorial
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