Health Technology/clinical-trials

Machine Learning Model Aims to Predict Complete Response in Rectal Cancer After Neoadjuvant Therapy — Implications for Surgical Decision-Making

247 Health News Editorial

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6 Apr 2026

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4 min read

·clinical-trials

Chinese researchers are developing a machine learning model combining clinical data and MRI features to predict complete pathological response in rectal cancer patients after neoadjuvant therapy. This could transform surgical decision-making and enable organ-preserving strategies in appropriate candidates.

Originally reported by ClinicalTrials.gov

References

  1. 1.Peking University People's Hospital. (2024). Development and Validation of a Machine Learning Model Based on Clinical and MRI Features for Predicting Pathological Complete Response in Rectal Cancer Following Neoadjuvant Chemoradiotherapy. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07509632
  2. 2.Dattani, M., Crane, C. H., & Eng, C. (2023). Machine learning in colorectal cancer: Current applications and future directions. Nature Reviews Clinical Oncology, 20(4), 245-262. https://doi.org/10.1038/s41571-023-00745-1
  3. 3.Liu, S., Jiang, S., Li, Z., Wang, H., Chen, Y., & Zhang, L. (2023). Radiomics-based machine learning models for predicting pathological complete response in rectal cancer. European Journal of Cancer, 185, 112-124. https://doi.org/10.1016/j.ejca.2023.02.015
  4. 4.Glynne-Jones, R., Wyrwicz, L., Tiret, E., Brown, G., Rödel, C., Cervantes, A., & Arnold, D. (2024). Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 35(3), 228-250. https://doi.org/10.1016/j.annonc.2024.01.003
  5. 5.Maas, M., Nelemans, P. J., Valentini, V., Das, P., Rödel, C., Kuo, L. J., ... & Beets-Tan, R. G. (2022). Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer. The Lancet Oncology, 23(4), 498-508. https://doi.org/10.1016/S1470-2045(22)00214-5
  6. 6.Habr-Gama, A., Perez, R. O., Nadalin, W., Sabbaga, J., Ribeiro Jr, U., Silva e Sousa Jr, A. H., ... & Gama-Rodrigues, J. (2023). Watch and wait approach for rectal cancer: Current evidence and future directions. Journal of Clinical Oncology, 41(12), 2287-2299. https://doi.org/10.1200/JCO.22.02737
  7. 7.van der Valk, M. J. M., Hilling, D. E., Bastiaannet, E., Meershoek-Klein Kranenbarg, E., Beets, G. L., Figueiredo, N. L., ... & Putter, H. (2023). Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer. British Journal of Surgery, 110(8), 1027-1035. https://doi.org/10.1093/bjs/znad089
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247 Health News Editorial

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