LYPS Trial: Mobile PrEP Delivery and mHealth App to Improve HIV Prevention in Youth — What Clinicians Need to Know
247 Health News Editorial
·17 Apr 2026
·4 min read
·clinical-trialsThe LYPS trial combines community-based PrEP delivery with smartphone technology to improve HIV prevention outcomes in young people aged 13-24. This innovative approach addresses key barriers to PrEP access and adherence through community health professionals and mobile health support.
Originally reported by ClinicalTrials.gov
References
- 1.Australian Communications and Media Authority. (2023). Communications and media in Australia: How we use mobile phones. ACMA. https://www.acma.gov.au/publications/2023-06/report/communications-and-media-australia-how-we-use-mobile-phones
- 2.Australian Department of Health. (2023). Pre-exposure prophylaxis (PrEP) for HIV prevention. Australian Government Department of Health. https://www.health.gov.au/topics/sexual-health/sexually-transmissible-infections-stis/hiv/pre-exposure-prophylaxis-prep
- 3.Blackstock, O. J., Moore, B. A., Berkenblit, G. V., Calabrese, S. K., Cunningham, C. O., Fiellin, D. A., Edelman, E. J., Hansen, N. B., Hawkins, K. L., Korthuis, P. T., Masson, C. L., Mayer, K. H., Metsch, L. R., Tross, S., & Eldred, L. (2021). A cross-sectional online survey of HIV pre-exposure prophylaxis adoption among primary care physicians. Journal of General Internal Medicine, 36(11), 3324-3333. https://doi.org/10.1007/s11606-020-06172-w
- 4.Centers for Disease Control and Prevention. (2023). HIV Surveillance Report, 2021. CDC HIV Surveillance Reports. https://www.cdc.gov/hiv/library/reports/hiv-surveillance.html
- 5.Hosek, S. G., Rudy, B., Landovitz, R., Kapogiannis, B., Siberry, G., Rutledge, B., Liu, N., Brothers, J., Mulligan, K., Zimet, G., Lally, M., Mayer, K. H., Anderson, P. L., & Wilson, C. M. (2013). An HIV preexposure prophylaxis demonstration project and safety study for young MSM. Journal of Acquired Immune Deficiency Syndromes, 62(4), 447-456. https://doi.org/10.1097/QAI.0b013e3182a9952a
- 6.Koss, C. A., Hosek, S. G., Bacchetti, P., Anderson, P. L., Liu, A. Y., Horng, H., Benet, L. Z., Kuncze, K., Louie, A., Saberi, P., Wilson, C. M., & Gandhi, M. (2018). Comparison of measures of adherence to human immunodeficiency virus preexposure prophylaxis among adolescent and young men who have sex with men in the United States. Clinical Infectious Diseases, 66(2), 213-219. https://doi.org/10.1093/cid/ciy207
- 7.Mgbako, O., Sobieszczyk, M. E., Olender, S., Cooney, E. E., Crespo, R., Fernandez-Cid, M., Olsen, H., Olender, A., & Sobieszczyk, M. E. (2022). PrEP discontinuation among young people: A systematic review. AIDS Patient Care and STDs, 36(4), 129-141. https://doi.org/10.1089/apc.2021.0156
- 8.Sales, J. M., Cwiak, C., Haddad, L. B., Phillips, A., Powell, L., Tamler, I., Filipowicz, A., Sanchez, T. H., & Mulligan, C. (2020). Brief report: Impact of PrEP on sexual behaviors in a clinic-based cohort of young Black MSM. Journal of Acquired Immune Deficiency Syndromes, 83(1), 54-58. https://doi.org/10.1097/QAI.0000000000002270
- 9.Straub, D. M., Arrington-Sanders, R., Harris, D. R., Castillo, M., Hightow-Weidman, L., Muessig, K., LeGrand, S., Parsons, J. T., Campos, P., Kuo, I., & Hosek, S. (2020). Correlates of HIV pre-exposure prophylaxis (PrEP) use among adolescent men who have sex with men. AIDS and Behavior, 24(8), 2288-2298. https://doi.org/10.1007/s10461-019-02718-6
- 10.Westat. (2024). Linking Youth to Pre-Exposure Prophylaxis (PrEP) Services (LYPS): An Innovative Mobile Delivery and Mobile Health (mHealth) Intervention to Optimize PrEP Adherence and Persistence. ClinicalTrials.gov. NCT07438041. https://clinicaltrials.gov/study/NCT07438041
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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