Health Technology/clinical-trials

Longitudinal Immune Profiling Study Aims to Predict Pancreatic Cancer Risk in Chronic Pancreatitis Patients — 800-Patient Cohort Opens

247 Health News Editorial

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13 June 2026

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4 min read

·clinical-trials

New 800-patient study will track immune system changes in chronic pancreatitis patients to predict pancreatic cancer risk. Longitudinal immune repertoire profiling could revolutionise surveillance strategies for high-risk patients.

Originally reported by ClinicalTrials.gov

References

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  2. 2.Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A. M., Gingras, M. C., ... & Grimmond, S. M. (2016). Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 531(7592), 47-52. https://doi.org/10.1038/nature16965
  3. 3.Ballehaninna, U. K., & Chamberlain, R. S. (2012). The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: an evidence based appraisal. Journal of Gastrointestinal Oncology, 3(2), 105-119. https://doi.org/10.3978/j.issn.2078-6891.2011.021
  4. 4.Canto, M. I., Harinck, F., Hruban, R. H., Offerhaus, G. J., Poley, J. W., Kamel, I., ... & Bruno, M. J. (2013). International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer. Gut, 62(3), 339-347. https://doi.org/10.1136/gutjnl-2012-303108
  5. 5.Changhai Hospital. (2024). Immune Repertoire Decoding Enables Dynamic Risk Stratification During Chronic Pancreatitis-to-Pancreatic Cancer Transition. ClinicalTrials.gov Identifier: NCT07612566. https://clinicaltrials.gov/study/NCT07612566
  6. 6.Kirkegård, J., Mortensen, F. V., & Cronin-Fenton, D. (2017). Chronic pancreatitis and pancreatic cancer risk: a systematic review and meta-analysis. American Journal of Gastroenterology, 112(9), 1366-1372. https://doi.org/10.1038/ajg.2017.218
  7. 7.Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R. W., Lankisch, P. G., Andersen, J. R., ... & Mullhaupt, B. (1993). Pancreatitis and the risk of pancreatic cancer. New England Journal of Medicine, 328(20), 1433-1437. https://doi.org/10.1056/NEJM199305203282001
  8. 8.Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023). Cancer statistics, 2023. CA: A Cancer Journal for Clinicians, 73(1), 233-254. https://doi.org/10.3322/caac.21763
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247 Health News Editorial

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