First Clinical Trial Confirms Safety and Efficacy of Intravaginal Bacillus Spore Probiotic Spray for Vaginitis
247 Health News Editorial
·5 Mar 2026
·5 min read
·clinical-trialsA randomised, double-blind trial of LiveSpo X-SECRET—a vaginal spray containing Bacillus subtilis, clausii, and coagulans spores—demonstrated a 5.7-fold reduction in symptoms, 275-fold decrease in G. vaginalis load, and 66% increase in vaginal IgA compared to saline control over 28 days, marking the first demonstrated clinical evidence for intravaginal Bacillus spore probiotics.
Originally reported by NCBI BioProject
References
- 1.Koumans, E. H., Sternberg, M., Bruce, C., McQuillan, G., Kendrick, J., Sutton, M., & Markowitz, L. E. (2007). The prevalence of bacterial vaginosis in the United States, 2001–2004; associations with symptoms, sexual behaviors, and reproductive health. Sexually Transmitted Diseases, 34(11), 864–869. https://doi.org/10.1097/OLQ.0b013e318074e565
- 2.Muzny, C. A., & Schwebke, J. R. (2016). Pathogenesis of bacterial vaginosis: discussion of current hypotheses. Journal of Infectious Diseases, 214(Suppl 1), S1–S5. https://doi.org/10.1093/infdis/jiw121
- 3.Bradshaw, C. S., & Sobel, J. D. (2016). Current treatment of bacterial vaginosis—limitations and need for innovation. Journal of Infectious Diseases, 214(Suppl 1), S14–S20. https://doi.org/10.1093/infdis/jiw039
- 4.Elshaghabee, F. M. F., Rokana, N., Gulhane, R. D., Sharma, C., & Panwar, H. (2017). Bacillus as potential probiotics: status, concerns, and future perspectives. Frontiers in Microbiology, 8, 1490. https://doi.org/10.3389/fmicb.2017.01490
- 5.Spobiotic Research Center / ANABIO R&D Ltd. Company. (2025). Effects of LiveSpo X-SECRET in Supportive Treatment of Vaginitis [BioProject PRJNA1269315; ClinicalTrials.gov NCT06165354]. NCBI BioProject. https://www.ncbi.nlm.nih.gov/bioproject/1269315
- 6.Spobiotic Research Center. (2025). Poster P-114: Intravaginal Bacillus spore probiotic spray in vaginitis management. Open Forum Infectious Diseases. https://academic.oup.com/ofid
- 7.Romero, R., Hassan, S. S., Gajer, P., Tarca, A. L., Fadrosh, D. W., Nikita, L., ... & Ravel, J. (2014). The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome, 2(1), 4. https://doi.org/10.1186/2049-2618-2-4
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247 Health News Editorial
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