Nasal Bacillus Spore Probiotic Spray Cuts Respiratory Infections in Preschool Children: First RCT Evidence

References

1. 1.GBD 2019 Diseases and Injuries Collaborators. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10258), 1204–1222. https://doi.org/10.1016/S0140-6736(20)30925-9
2. 2.Rhedin, S., Lindstrand, A., Hjelmgren, A., Ryd-Rinder, M., Öhrmalm, L., Tolfvenstam, T., ... & Naucler, P. (2015). Respiratory viruses associated with community-acquired pneumonia in children: matched case-control study. Thorax, 70(5), 430–435. https://doi.org/10.1136/thoraxjnl-2014-206141
3. 3.Hersh, A. L., Shapiro, D. J., Pavia, A. T., & Shah, S. S. (2011). Antibiotic prescribing in ambulatory pediatrics in the United States. Pediatrics, 128(6), 1053–1061. https://doi.org/10.1542/peds.2011-1337
4. 4.Lauber, C. L., Zhou, N., Gordon, J. I., Knight, R., & Fierer, N. (2010). Effect of storage conditions on the assessment of bacterial community structure in soil and human-associated samples. FEMS Microbiology Letters, 307(1), 80–86. https://doi.org/10.1111/j.1574-6968.2010.02185.x
5. 5.Spobiotic Research Center / ANABIO R&D Ltd. Company. (2025). Efficacy of Probiotics (LiveSpo Navax) in Preventing Respiratory Diseases in Children [BioProject PRJNA1259757; ClinicalTrials.gov NCT06148194]. NCBI BioProject. https://www.ncbi.nlm.nih.gov/bioproject/1259757
6. 6.ANABIO R&D Ltd. / Hanoi Medical University research group. (2024). Safety and efficacy of nasal spray Bacillus spore probiotics (LiveSpo Navax) for upper respiratory tract infection prevention in preschool children. Scientific Reports. https://www.nature.com/scientificreports/
7. 7.Stein, T. (2005). Bacillus subtilis antibiotics: structures, syntheses and specific functions. Molecular Microbiology, 56(4), 845–857. https://doi.org/10.1111/j.1365-2958.2005.04682.x
8. 8.Lefevre, M., Racedo, S. M., Ripert, G., Housez, B., Cazaubiel, M., Maudet, C., ... & Urdaci, M. C. (2015). Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study. Immunity & Ageing, 12, 24. https://doi.org/10.1186/s12979-015-0051-y