LETHE Pilot Trial Completed: Digital Lifestyle Intervention Shows Promise for Dementia Prevention in At-Risk Older Adults

References

1. 1.Finnish Institute for Health and Welfare. (2022). Digitally Supported Lifestyle Programme to Promote Brain Health Among Older Adults - the LETHE Pilot Trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05565170
2. 2.Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189-198. https://doi.org/10.1016/0022-3956(75)90026-6
3. 3.Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018). Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nature Reviews Neurology, 14(11), 653-666. https://doi.org/10.1038/s41582-018-0070-3
4. 4.Kivipelto, M., Ngandu, T., Laatikainen, T., Winblad, B., Soininen, H., & Tuomilehto, J. (2006). Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. The Lancet Neurology, 5(9), 735-741. https://doi.org/10.1016/S1474-4422(06)70537-3
5. 5.Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., ... & Mukadam, N. (2020). Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet, 396(10248), 413-446. https://doi.org/10.1016/S0140-6736(20)30367-6
6. 6.Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., ... & Kivipelto, M. (2015). A 2 year multidomain intervention to prevent cognitive decline: a randomised controlled trial (FINGER). The Lancet, 385(9984), 2255-2263. https://doi.org/10.1016/S0140-6736(15)60461-5
7. 7.Solomon, A., Turunen, H., Ngandu, T., Peltonen, M., Levälahti, E., Helisalmi, S., ... & Kivipelto, M. (2018). Effect of the apolipoprotein E genotype on cognitive change during a multidomain lifestyle intervention: a subgroup analysis of a randomised controlled trial. JAMA Neurology, 75(4), 462-470. https://doi.org/10.1001/jamaneurol.2017.3918
8. 8.World Health Organization. (2023). Dementia: Key Facts. WHO Fact Sheets. https://www.who.int/news-room/fact-sheets/detail/dementia