LEARN Trial Advances Markerless Tracking in Radiation Therapy — Australian Multi-Site Study Recruiting 300 Patients
247 Health News Editorial
·27 May 2026
·4 min read
·clinical-trialsThe LEARN trial is developing revolutionary markerless tracking technology for radiation therapy across multiple cancer types. This University of Sydney study is recruiting 300 patients to advance real-time tumour motion monitoring without invasive markers.
Originally reported by ClinicalTrials.gov
References
- 1.Australian Institute of Health and Welfare. (2023). Cancer in Australia 2023 (CAN 144). AIHW. https://www.aihw.gov.au/reports/cancer/cancer-in-australia-2023
- 2.Berbeco, R. I., Nishioka, S., Shirato, H., Chen, G. T., & Jiang, S. B. (2005). Residual motion of lung tumours in gated radiotherapy with external respiratory surrogates. Physics in Medicine & Biology, 50(16), 3655-3667. https://doi.org/10.1088/0031-9155/50/16/020
- 3.Dawson, L. A., & Sharpe, M. B. (2006). Image-guided radiotherapy: rationale, benefits, and limitations. The Lancet Oncology, 7(10), 848-858. https://doi.org/10.1016/S1470-2045(06)70991-4
- 4.Jaffray, D. A. (2012). Image-guided radiotherapy: from current concept to future perspectives. Nature Reviews Clinical Oncology, 9(12), 688-699. https://doi.org/10.1038/nrclinonc.2012.194
- 5.Keall, P. J., Mageras, G. S., Balter, J. M., Emery, R. S., Forster, K. M., Jiang, S. B., Kapatoes, J. M., Low, D. A., Murphy, M. J., Murray, B. R., Ramsey, C. R., Van Herk, M. B., Vedam, S. S., Wong, J. W., & Yorke, E. (2006). The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Medical Physics, 33(10), 3874-3900. https://doi.org/10.1118/1.2349696
- 6.Langen, K. M., & Jones, D. T. (2001). Organ motion and its management. International Journal of Radiation Oncology Biology Physics, 50(1), 265-278. https://doi.org/10.1016/S0360-3016(01)01453-5
- 7.Shirato, H., Shimizu, S., Kitamura, K., Nishioka, T., Kagei, K., Hashimoto, S., Aoyama, H., Kunieda, T., Shinohara, N., Dosaka-Akita, H., & Miyasaka, K. (2000). Four-dimensional treatment planning and fluoroscopic real-time tumor tracking radiotherapy for moving tumor. International Journal of Radiation Oncology Biology Physics, 48(2), 435-442. https://doi.org/10.1016/S0360-3016(00)00625-8
- 8.University of Sydney. (2024). LEARN: Learning Environment for Artificial Intelligence in Radiotherapy New Technology. ClinicalTrials.gov. NCT05184790. https://clinicaltrials.gov/study/NCT05184790
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