Health Technology/clinical-trials

LEARN Trial Advances Markerless Tracking in Radiation Therapy — Australian Multi-Site Study Recruiting 300 Patients

247 Health News Editorial

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27 May 2026

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4 min read

·clinical-trials

The LEARN trial is developing revolutionary markerless tracking technology for radiation therapy across multiple cancer types. This University of Sydney study is recruiting 300 patients to advance real-time tumour motion monitoring without invasive markers.

Originally reported by ClinicalTrials.gov

References

  1. 1.Australian Institute of Health and Welfare. (2023). Cancer in Australia 2023 (CAN 144). AIHW. https://www.aihw.gov.au/reports/cancer/cancer-in-australia-2023
  2. 2.Berbeco, R. I., Nishioka, S., Shirato, H., Chen, G. T., & Jiang, S. B. (2005). Residual motion of lung tumours in gated radiotherapy with external respiratory surrogates. Physics in Medicine & Biology, 50(16), 3655-3667. https://doi.org/10.1088/0031-9155/50/16/020
  3. 3.Dawson, L. A., & Sharpe, M. B. (2006). Image-guided radiotherapy: rationale, benefits, and limitations. The Lancet Oncology, 7(10), 848-858. https://doi.org/10.1016/S1470-2045(06)70991-4
  4. 4.Jaffray, D. A. (2012). Image-guided radiotherapy: from current concept to future perspectives. Nature Reviews Clinical Oncology, 9(12), 688-699. https://doi.org/10.1038/nrclinonc.2012.194
  5. 5.Keall, P. J., Mageras, G. S., Balter, J. M., Emery, R. S., Forster, K. M., Jiang, S. B., Kapatoes, J. M., Low, D. A., Murphy, M. J., Murray, B. R., Ramsey, C. R., Van Herk, M. B., Vedam, S. S., Wong, J. W., & Yorke, E. (2006). The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Medical Physics, 33(10), 3874-3900. https://doi.org/10.1118/1.2349696
  6. 6.Langen, K. M., & Jones, D. T. (2001). Organ motion and its management. International Journal of Radiation Oncology Biology Physics, 50(1), 265-278. https://doi.org/10.1016/S0360-3016(01)01453-5
  7. 7.Shirato, H., Shimizu, S., Kitamura, K., Nishioka, T., Kagei, K., Hashimoto, S., Aoyama, H., Kunieda, T., Shinohara, N., Dosaka-Akita, H., & Miyasaka, K. (2000). Four-dimensional treatment planning and fluoroscopic real-time tumor tracking radiotherapy for moving tumor. International Journal of Radiation Oncology Biology Physics, 48(2), 435-442. https://doi.org/10.1016/S0360-3016(00)00625-8
  8. 8.University of Sydney. (2024). LEARN: Learning Environment for Artificial Intelligence in Radiotherapy New Technology. ClinicalTrials.gov. NCT05184790. https://clinicaltrials.gov/study/NCT05184790
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247 Health News Editorial

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