Health Technology/clinical-trials

Large-Scale Real-World Study Develops AI Tool for Ulinastatin Response Prediction in Cardiac Surgery — 10,000-Patient Chinese Cohort

247 Health News Editorial

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20 May 2026

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4 min read

·clinical-trials

Chinese researchers are developing an AI tool to predict which cardiac surgery patients will respond to ulinastatin treatment, analyzing data from 10,000 patients across four major cardiac centers. The study aims to enable personalized anti-inflammatory therapy in cardiac surgery.

Originally reported by ClinicalTrials.gov

References

  1. 1.Beijing Anzhen Hospital. (2024). Development and validation of an AI-based tool for identifying responders and stratifying risks in ulinastatin treatment in cardiac surgery: A multicenter real-world study. ClinicalTrials.gov. NCT07583290. https://clinicaltrials.gov/study/NCT07583290
  2. 2.Leng, Y., Xie, J., Jiang, L., Guo, Y., Liu, Y., & Liu, L. (2022). Ulinastatin for cardiac surgery: a systematic review and meta-analysis of randomized controlled trials. Critical Care, 26(1), 180. https://doi.org/10.1186/s13054-022-04053-4
  3. 3.Milne, B., Gilbey, T., & Kunst, G. (2019). Perioperative management of the patient for cardiac surgery. Anaesthesia, 74(S1), 67-72. https://doi.org/10.1111/anae.14478
  4. 4.Squiccimarro, E., Labriola, C., Malvindi, P. G., Margari, V., Guida, P., Visicchio, G., Kounakis, G., Favale, A., Dambruoso, P., Mastrototaro, G., Lorusso, R., & Paparella, D. (2017). Prevalence and clinical impact of systemic inflammatory reaction after cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia, 31(4), 1382-1390. https://doi.org/10.1053/j.jvca.2016.11.013
  5. 5.Wang, C., Xie, N., Wang, M., Tan, Y., Cai, H., & Wu, Y. (2021). Evaluation of perioperative ulinastatin on postoperative outcomes in cardiac surgery: a meta-analysis. Medicine, 100(44), e27893. https://doi.org/10.1097/MD.0000000000027893
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