Large-Scale Observational Study Develops AI Model to Predict Complications in Pediatric VSD Closure — 5,249 Patient Registry
247 Health News Editorial
·11 Apr 2026
·4 min read
·clinical-trialsLarge observational study develops AI prediction model for complications in paediatric transcatheter VSD closure using data from 5,249 patients. Research aims to improve risk stratification and patient selection for interventional procedures.
Originally reported by ClinicalTrials.gov
References
- 1.Xinhua Hospital Research Team. (2024). Multimodal Clinical Data Integration and Artificial Intelligence Modeling for Predicting Complications Following Pediatric Transcatheter Closure of Perimembranous Ventricular Septal Defect. ClinicalTrials.gov. NCT07375602. https://clinicaltrials.gov/study/NCT07375602
- 2.Holzer, R., de Giovanni, J., Walsh, K. P., Tometzki, A., Goh, T., Hakim, F., Hijazi, Z. M., & Amplatzer Investigators. (2006). Transcatheter closure of perimembranous ventricular septal defects using the amplatzer membranous VSD occluder: immediate and midterm results of an international registry. Catheterization and Cardiovascular Interventions, 68(4), 620-628. https://doi.org/10.1002/ccd.20694
- 3.Hoffman, J. I., & Kaplan, S. (2002). The incidence of congenital heart disease. Journal of the American College of Cardiology, 39(12), 1890-1900. https://doi.org/10.1016/S0735-1097(02)01886-7
- 4.Carminati, M., Butera, G., Chessa, M., De Giovanni, J., Fisher, G., Gewillig, M., Peuster, M., Piechaud, J. F., Santoro, G., Sievert, H., Spadoni, I., & Walsh, K. (2007). Transcatheter closure of congenital ventricular septal defects: results of the European Registry. European Heart Journal, 28(19), 2361-2368. https://doi.org/10.1093/eurheartj/ehm314
- 5.Rajpurkar, P., Chen, E., Banerjee, O., & Topol, E. J. (2022). AI in health and medicine. Nature Medicine, 28(1), 31-38. https://doi.org/10.1038/s41591-021-01614-0
- 6.Collins, G. S., Reitsma, J. B., Altman, D. G., & Moons, K. G. (2015). Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. BMJ, 350, g7594. https://doi.org/10.1136/bmj.g7594
- 7.Butera, G., Carminati, M., Chessa, M., Youssef, R., Drago, M., Giamberti, A., Pome, G., Bossone, E., & Frigiola, A. (2006). Percutaneous versus surgical closure of ventricular septal defects in children and adolescents. Journal of the American College of Cardiology, 48(6), 1204-1210. https://doi.org/10.1016/j.jacc.2006.01.067
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