Health Technology/clinical-trials

INTRUDE Trial: fMRI-Guided Neurofeedback vs Sham for Treatment-Resistant Auditory Hallucinations in Schizophrenia

247 Health News Editorial

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26 May 2026

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4 min read

·clinical-trials

The INTRUDE trial investigates fMRI-guided neurofeedback for treatment-resistant auditory hallucinations in schizophrenia. This innovative approach uses real-time brain imaging to train patients to control hallucination-related neural activity patterns.

Originally reported by ClinicalTrials.gov

References

  1. 1.University Hospital, Lille. (2024). Treat refractory auditory hallucinations in schizophrenia patients with fMRI-guided neurofeedback: A randomized-controlled trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT04798131
  2. 2.Geoffroy, P. A., Fovet, T., Jardon, V., Barantin, L., Bordet, R., Amad, A., & Jardri, R. (2022). Real-time fMRI neurofeedback in psychiatry: A systematic review. Psychiatry Research, 317, 114578. https://doi.org/10.1016/j.psychres.2022.114578
  3. 3.Corlett, P. R., Horga, G., Fletcher, P. C., Alderson-Day, B., Schmack, K., & Powers, A. R. (2019). Hallucinations and strong priors. Trends in Cognitive Sciences, 23(2), 114-127. https://doi.org/10.1016/j.tics.2019.04.005
  4. 4.Tursic, A., Eck, J., Lührs, M., Linden, D. E., & Goebel, R. (2021). A systematic review of fMRI neurofeedback reporting and effects in clinical populations. NeuroImage: Clinical, 28, 102648. https://doi.org/10.1016/j.nicl.2021.102648
  5. 5.Shinn, A. K., Pfaff, D., Young, S., Lewandowski, K. E., Cohen, B. M., & Öngür, D. (2012). A systematic review of the treatment of auditory hallucinations in schizophrenia. Schizophrenia Research, 137(1-3), 192-199. https://doi.org/10.1016/j.schres.2012.08.019
  6. 6.Waters, F., Allen, P., Aleman, A., Fernyhough, C., Woodward, T. S., Badcock, J. C., ... & Larøi, F. (2012). Auditory hallucinations in schizophrenia and nonschizophrenia populations: A review and integrated model of cognitive mechanisms. Schizophrenia Bulletin, 38(4), 683-693. https://doi.org/10.1093/schbul/sbs045
  7. 7.Leucht, S., Leucht, C., Huhn, M., Chaimani, A., Mavridis, D., Helfer, B., ... & Davis, J. M. (2017). Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Systematic review, bayesian meta-analysis, and meta-regression of efficacy predictors. American Journal of Psychiatry, 174(10), 927-942. https://doi.org/10.1176/appi.ajp.2017.16121358
  8. 8.Slotema, C. W., Blom, J. D., Hoek, H. W., & Sommer, I. E. (2014). Review of the efficacy of transcranial magnetic stimulation for auditory verbal hallucinations. Biological Psychiatry, 76(2), 101-110. https://doi.org/10.1016/j.biopsych.2013.09.038
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247 Health News Editorial

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