International AI-Driven Coronary Plaque Risk Stratification Study Opens — Implications for Australian Cardiology Practice
247 Health News Editorial
·14 June 2026
·4 min read
·clinical-trialsThe RUSTWORTHY study is developing AI-driven tools to identify high-risk coronary plaques using advanced CCTA analysis. This 4,000-patient Italian study could revolutionise cardiovascular risk prediction and patient stratification.
Originally reported by ClinicalTrials.gov
References
- 1.Centro Cardiologico Monzino. (2024). Rustworthy, Integrated Artificial Intelligence Tools for Predicting High-risk CORonary PlaqueS. ClinicalTrials.gov. NCT06410690. https://clinicaltrials.gov/study/NCT06410690
- 2.Kolossváry, M., Kellermayer, M., Merkely, B., & Maurovich-Horvat, P. (2019). Cardiac computed tomography radiomics: a comprehensive review on radiomic techniques. Journal of Thoracic Imaging, 34(1), 26-34. https://doi.org/10.1097/RTI.0000000000000394
- 3.Oikonomou, E. K., Williams, M. C., Kotanidis, C. P., Desai, M. Y., Marwan, M., Antonopoulos, A. S., Thomas, K. E., Thomas, S., Akoumianakis, I., Fan, L. M., Kesavan, S., Herdman, L., Alashi, A., Centeno, E. H., Lyasheva, M., Griffin, B. P., Flamm, S. D., Shirodaria, C., Sabharwal, N., ... Antoniades, C. (2019). A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. European Heart Journal, 40(43), 3529-3543. https://doi.org/10.1093/eurheartj/ehz592
- 4.Commandeur, F., Goeller, M., Betancur, J., Cadet, S., Doris, M., Chen, X., Berman, D. S., Slomka, P. J., Tamarappoo, B. K., & Dey, D. (2018). Deep learning for quantification of epicardial and thoracic adipose tissue from non-contrast CT. IEEE Transactions on Medical Imaging, 37(8), 1835-1846. https://doi.org/10.1109/TMI.2018.2804799
- 5.Genders, T. S., Steyerberg, E. W., Alkadhi, H., Leschka, S., Desbiolles, L., Nieman, K., Galema, T. W., Meijboom, W. B., Mollet, N. R., de Feyter, P. J., Cademartiri, F., Maffei, E., Dewey, M., Zimmermann, E., Laule, M., Pugliese, F., Barbagallo, R., Sinitsyn, V., Bogaert, J., ... Hunink, M. M. (2011). A clinical prediction rule for the diagnosis of coronary artery disease: validation, updating, and extension. European Heart Journal, 32(11), 1316-1330. https://doi.org/10.1093/eurheartj/ehr014
- 6.Roth, G. A., Mensah, G. A., Johnson, C. O., Addolorato, G., Ammirati, E., Baddour, L. M., Barengo, N. C., Beaton, A. Z., Benjamin, E. J., Benziger, C. P., Bonny, A., Brauer, M., Brodmann, M., Cahill, T. J., Carapetis, J., Catapano, A. L., Chugh, S. S., Cooper, L. T., Coresh, J., ... GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group. (2020). Global burden of cardiovascular diseases and risk factors, 1990–2019. Journal of the American College of Cardiology, 76(25), 2982-3021. https://doi.org/10.1016/j.jacc.2020.11.010
- 7.Libby, P., Pasterkamp, G., Crea, F., & Jang, I. K. (2019). Reassessing the mechanisms of acute coronary syndromes. Circulation Research, 124(1), 150-160. https://doi.org/10.1161/CIRCRESAHA.118.311098
- 8.Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott, E., Storey, R. F., Deaton, C., Cuisset, T., Agewall, S., Dickstein, K., Edvardsen, T., Escaned, J., Gersh, B. J., Svitil, P., Gilard, M., Hasdai, D., Hatala, R., ... ESC Scientific Document Group. (2020). 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal, 41(3), 407-477. https://doi.org/10.1093/eurheartj/ehz425
2
247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
Related Articles
clinical-trials
Digital Health Platform vs Case Manager Support in Hypertension Management: Taiwan's 1,726-Participant Trial Signals a Shift in Blood Pressure Care Delivery
3 Aug 2026
clinical-trials
Phase II Trial: AI-Powered Wysa Chatbot vs Unmet Need — Digital Eating Disorder Prevention in At-Risk Adolescents
3 Aug 2026
clinical-trials
Pilot Trial Targets the Inpatient-to-Outpatient Gap: Digital Smoking Cessation Intervention for Persons With Serious Mental Illness — Key Findings for Clinicians
3 Aug 2026
This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service