Incretin-Based Therapy and Respiratory Function in Obesity: New Trial to Deploy Machine Learning for Predicting Pulmonary Outcomes
247 Health News Editorial
·8 July 2026
·5 min read
·clinical-trialsA new clinical trial from Biruni University is set to investigate how incretin-based therapies — including GLP-1 receptor agonists — affect respiratory muscle strength, pulmonary function, and ventilatory responses in adults with obesity. Uniquely, the study will apply machine learning to baseline clinical data to predict which patients are most likely to achieve respiratory benefit, potentially reshaping how clinicians monitor and manage pulmonary outcomes in obesity pharmacotherapy.
Originally reported by ClinicalTrials.gov
References
- 1.Biruni University. (2025). Prediction of changes in pulmonary function, respiratory muscle performance, and ventilatory responses following incretin-based therapy in individuals with obesity using machine learning (NCT07663591). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07663591
- 2.Salome, C. M., King, G. G., & Berend, N. (2010). Physiology of obesity and effects on lung function. Journal of Applied Physiology, 108(1), 206–211. https://doi.org/10.1152/japplphysiol.00694.2009
- 3.Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., Kiyosue, A., Zhang, S., Liu, B., Bunck, M. C., & Stefanski, A. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205–216. https://doi.org/10.1056/NEJMoa2206038
- 4.Evans, J. A., & Whitelaw, W. A. (2009). The assessment of maximal respiratory mouth pressures in adults. Respiratory Care, 54(10), 1348–1359. https://doi.org/10.4187/002013209790514386
- 5.Malhotra, A., Grunstein, R. R., Fietze, I., Weaver, T. E., Redline, S., Azarbarzin, A., Sands, S. A., Schwab, R. J., Dunn, J. P., Chakladar, S., Bunck, M. C., & Bednarik, J. (2023). Tirzepatide for the treatment of obstructive sleep apnea and obesity. New England Journal of Medicine, 391(13), 1193–1205. https://doi.org/10.1056/NEJMoa2404881
- 6.Wilding, J. P. H., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., McGowan, B. M., Rosenstock, J., Tran, M. T. D., Wadden, T. A., Wharton, S., Yokote, K., Zeuthen, N., & Kushner, R. F. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/NEJMoa2032183
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247 Health News Editorial
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