Health Technology/clinical-trials

IMPROVE Trial: MRI-Guided Risk Assessment vs Standard Care for Carotid Revascularisation — Non-Inferiority Study Opens

247 Health News Editorial

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23 May 2026

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4 min read

·clinical-trials

The IMPROVE trial investigates whether MRI-based plaque assessment can improve patient selection for carotid revascularisation compared to standard care. This Dutch multicentre study could revolutionise stroke prevention by identifying vulnerable plaques beyond traditional stenosis measurements.

Originally reported by ClinicalTrials.gov

References

  1. 1.Gupta, A., Baradaran, H., Schweitzer, A. D., Kamel, H., Pandya, A., Delgado, D., ... & Mushlin, A. I. (2013). Carotid plaque MRI and stroke risk: a systematic review and meta-analysis. Stroke, 44(11), 3071-3077. https://doi.org/10.1161/STROKEAHA.113.002551
  2. 2.Maastricht University Medical Center. (2024). Clinical Impact of the Use of IMPROVE for Selection of Patients for Carotid Revascularisation. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07556887
  3. 3.National Stroke Foundation. (2017). Clinical Guidelines for Stroke Management. Stroke Foundation Australia.
  4. 4.Naylor, A. R., Ricco, J. B., de Borst, G. J., Debus, S., de Haro, J., Halliday, A., ... & Esvs Guidelines Committee. (2018). Editor's choice–management of atherosclerotic carotid and vertebral artery disease: 2017 clinical practice guidelines of the European Society for Vascular Surgery. European Journal of Vascular and Endovascular Surgery, 55(1), 3-81. https://doi.org/10.1016/j.ejvs.2017.06.021
  5. 5.Rothwell, P. M., Eliasziw, M., Gutnikov, S. A., Fox, A. J., Taylor, D. W., Mayberg, M. R., ... & Barnett, H. J. (2003). Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis. The Lancet, 361(9352), 107-116. https://doi.org/10.1016/S0140-6736(03)12228-3
  6. 6.Saam, T., Hetterich, H., Hoffmann, V., Yuan, C., Dichgans, M., Poppert, H., ... & Reiser, M. F. (2019). Meta-analysis and systematic review of the predictive value of carotid plaque hemorrhage on cerebrovascular events by magnetic resonance imaging. Journal of the American College of Cardiology, 73(11), 1278-1287. https://doi.org/10.1016/j.jacc.2019.06.081
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247 Health News Editorial

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