HOMA-PULSE Trial: Can Insulin Resistance Predict Pulsed Field Ablation Success in Atrial Fibrillation?
247 Health News Editorial
·3 May 2026
·4 min read
·clinical-trialsThe HOMA-PULSE trial investigates whether insulin resistance can predict pulsed field ablation success in atrial fibrillation patients. This Czech study examines HOMA-IR as a potential biomarker for ablation outcomes in 120 non-diabetic patients.
Originally reported by ClinicalTrials.gov
References
- 1.Calkins, H., Hindricks, G., Cappato, R., Kim, Y. H., Saad, E. B., Aguinaga, L., ... & Yamane, T. (2017). 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Heart Rhythm, 14(10), e275-e444. https://doi.org/10.1016/j.hrthm.2017.05.012
- 2.Fontes, J. D., Lyass, A., Massaro, J. M., Rienstra, M., Dallmeier, D., Schnabel, R. B., ... & Benjamin, E. J. (2012). Insulin resistance and atrial fibrillation (from the Framingham Heart Study). American Journal of Cardiology, 109(1), 87-90. https://doi.org/10.1016/j.amjcard.2012.03.032
- 3.Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström-Lundqvist, C., ... & Watkins, C. L. (2020). 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). European Heart Journal, 42(5), 373-498. https://doi.org/10.1093/eurheartj/ehaa612
- 4.Huxley, R. R., Filion, K. B., Konety, S., & Alonso, A. (2012). Meta-analysis of cohort and case-control studies of type 2 diabetes mellitus and risk of atrial fibrillation. American Journal of Cardiology, 109(1), 56-62. https://doi.org/10.1016/j.amjcard.2011.12.014
- 5.Nemocnice AGEL Trinec-Podlesi a.s. (2024). HOMA-PULSE: Assessment of glucose metabolism and insulin resistance as a predictor of pulsed field ablation success in atrial fibrillation. ClinicalTrials.gov. NCT07551947. https://clinicaltrials.gov/study/NCT07551947
- 6.Reddy, V. Y., Neuzil, P., Koruth, J. S., Petru, J., Funosako, M., Cochet, H., ... & Dukkipati, S. R. (2018). Pulsed field ablation for pulmonary vein isolation in atrial fibrillation. Journal of the American College of Cardiology, 71(14), 1560-1570. https://doi.org/10.1016/j.jacc.2018.04.021
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