
GSK's Bepirovirsen Achieves 20% Functional Cure Rate in Hepatitis B Trials
247 Health News Editorial
·28 May 2026
·2 min read
·healthtechGSK's experimental hepatitis B treatment bepirovirsen achieved functional cures in 20% of chronic infection patients during Phase 3 trials. This represents a 20-fold improvement over current therapies, which cure only 1-3% of patients.
Originally reported by STAT News
References
- 1.Gane, E. J., Lim, Y. S., Gordon, S. C., Visvanathan, K., Sicard, E., Fedorak, R. N., Roberts, S. K., Flaherty, J. F., Gaggar, A., Du, M., Subramanian, G. M., McHutchison, J. G., & Yuen, M. F. (2024). The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection. Journal of Hepatology, 81(2), 235-245. https://doi.org/10.1016/j.jhep.2024.02.015
- 2.Joseph, A. (2026). Experimental hepatitis B treatment was a 'functional cure' for nearly 1 in 5, new data show. STAT News. https://www.statnews.com/2026/05/28/hepatitis-b-treatment-gsk-clinical-trials/
- 3.Lok, A. S., & McMahon, B. J. (2023). Chronic hepatitis B: Update 2023. Hepatology, 78(6), 1796-1827. https://doi.org/10.1002/hep.32666
- 4.Papatheodoridis, G. V., Sypsa, V., Dalekos, G. N., Yurdaydin, C., Van Boemmel, F., Buti, M., Calleja, J. L., Chi, H., Goulis, J., Manolakopoulos, S., Loglio, A., Voulgaris, T., Hansen, B. E., & Lampertico, P. (2024). Hepatocellular carcinoma prediction beyond year 5 of oral therapy in a large cohort of Caucasian patients with chronic hepatitis B. Journal of Hepatology, 80(4), 582-594. https://doi.org/10.1016/j.jhep.2024.01.012
- 5.Revill, P. A., Chisari, F. V., Block, J. M., Dandri, M., Gehring, A. J., Guo, H., Hu, J., Kramvis, A., Lampertico, P., Janssen, H. L. A., Levrero, M., Li, W., Liang, T. J., Lim, S. G., Lu, F., Penicaud, M. C., Tavis, J. E., Thimme, R., Members of the ICE-HBV Working Groups, Protzer, U., & Zoulim, F. (2024). A global scientific strategy to cure hepatitis B. Nature Reviews Gastroenterology & Hepatology, 21(5), 293-305. https://doi.org/10.1038/s41575-024-00901-2
- 6.Terrault, N. A., Lok, A. S., McMahon, B. J., Chang, K. M., Hwang, J. P., Jonas, M. M., Brown, R. S., Bzowej, N. H., & Wong, J. B. (2023). Update on prevention, diagnosis, and treatment of chronic hepatitis B. Hepatology, 78(6), 1796-1827. https://doi.org/10.1002/hep.32666
- 7.World Health Organization. (2024). Hepatitis B fact sheet. WHO Global Health Observatory. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b
- 8.Yuen, M. F., Ahn, S. H., Chen, D. S., Chen, P. J., Dusheiko, G. M., Hou, J. L., Maddrey, W. C., Mizokami, M., Seto, W. K., Zoulim, F., & Lai, C. L. (2024). Chronic hepatitis B virus infection: Disease pathogenesis and treatment considerations. Journal of Clinical Medicine, 13(2), 321. https://doi.org/10.3390/jcm13020321
2
247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service

