Health Technology/clinical-trials

German Trial Tests Machine Learning Algorithm to Predict Postoperative Pulmonary Complications — Early Detection Strategy for Perioperative Care

247 Health News Editorial

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13 May 2026

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3 min read

·clinical-trials

German researchers are testing a machine learning algorithm to predict postoperative pulmonary complications before they become clinically apparent. The PEPPERMINT trial combines routine clinical data with bedside ultrasound to identify high-risk surgical patients.

Originally reported by ClinicalTrials.gov

References

  1. 1.Trautwein, B. (2023). PrEventing PostoPERative Pulmonary Complications by Establishing a MachINe-learning assisTed Approach [Clinical trial registration NCT05789953]. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05789953
  2. 2.Fernandez-Bustamante, A., Frendl, G., Sprung, J., Kor, D. J., Subramaniam, B., Ruiz, R. M., ... & Vidal Melo, M. F. (2017). Postoperative pulmonary complications, early mortality, and hospital stay following noncardiothoracic surgery: a multicenter study by the perioperative research network investigators. JAMA Surgery, 152(2), 157-166. https://doi.org/10.1001/jamasurg.2017.1332
  3. 3.Miskovic, A., & Lumb, A. B. (2017). Postoperative pulmonary complications. British Journal of Anaesthesia, 118(3), 317-334. https://doi.org/10.1093/bja/aex002
  4. 4.Canet, J., Gallart, L., Gomar, C., Paluzie, G., Vallès, J., Castillo, J., ... & Mazo, V. (2010). Prediction of postoperative pulmonary complications in a population-based surgical cohort. Anesthesiology, 113(6), 1338-1350. https://doi.org/10.1097/ALN.0b013e3181fc6e0a
  5. 5.Mazo, V., Sabaté, S., Canet, J., Gallart, L., de Abreu, M. G., Belda, J., ... & Pelosi, P. (2014). Prospective external validation of a predictive score for postoperative pulmonary complications. Anesthesiology, 121(2), 219-231. https://doi.org/10.1097/ALN.0000000000000334
  6. 6.Serpa Neto, A., Hemmes, S. N., Barbas, C. S., Beiderlinden, M., Fernandez-Bustamante, A., Futier, E., ... & Schultz, M. J. (2014). Incidence of mortality and morbidity related to postoperative lung injury in patients who have undergone abdominal or thoracic surgery: a systematic review and meta-analysis. The Lancet Respiratory Medicine, 2(12), 1007-1015. https://doi.org/10.1016/S2213-2600(14)70228-0
  7. 7.Monastesse, A., Girard, F., Massicotte, N., Chartrand-Lefebvre, C., & Girard, M. (2017). Point-of-care lung ultrasound in the assessment of perioperative lung injury: an observational study. Canadian Journal of Anaesthesia, 64(9), 946-955. https://doi.org/10.1007/s12630-017-0917-0
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