Health Technology/clinical-trials

French Study Validates Wearable Sensors for CMT1A Monitoring — Digital Biomarkers Could Transform Neuropathy Care

247 Health News Editorial

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8 June 2026

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4 min read

·clinical-trials

French researchers are validating wearable sensors as digital biomarkers for CMT1A monitoring. This 60-patient study could transform how clinicians track disease progression in hereditary peripheral neuropathy.

Originally reported by ClinicalTrials.gov

References

  1. 1.Barreto, L. C., Oliveira, F. S., Nunes, P. S., de França Costa, I. M., Garcez, C. A., Goes, G. M., ... & Neves, E. L. (2016). Epidemiologic study of Charcot-Marie-Tooth disease: a systematic review. Neuroepidemiology, 46(3), 157-165. https://doi.org/10.1159/000443706
  2. 2.Cornett, K. M., Menezes, M. P., Bray, P., Halaki, M., Shy, R. R., Yum, S. W., ... & Burns, J. (2016). Phenotypic variability of childhood Charcot-Marie-Tooth disease. JAMA Neurology, 73(6), 645-651. https://doi.org/10.1001/jamaneurol.2016.2734
  3. 3.Fridman, V., Bundy, B., Reilly, M. M., Pareyson, D., Bacon, C., Burns, J., ... & Shy, M. E. (2015). CMT subtypes and disease burden in patients enrolled in the Inherited Neuropathies Consortium natural history study: a cross-sectional analysis. Journal of Neurology, Neurosurgery & Psychiatry, 86(8), 873-878. https://doi.org/10.1136/jnnp-2014-308826
  4. 4.Mandarakas, M. R., Rose, K. J., Famula, J. A., Reilly, M. M., Shy, M. E., & Burns, J. (2018). Development and validation of the CMT Pediatric Scale. Neurology, 91(6), e561-e570. https://doi.org/10.1212/WNL.0000000000006074
  5. 5.Piscosquito, G., Reilly, M. M., Schenone, A., Fabrizi, G. M., Cavallaro, T., Santoro, L., ... & Pareyson, D. (2015). Responsiveness of clinical outcome measures in Charcot-Marie-Tooth disease. European Journal of Neurology, 22(8), 1102-1109. https://doi.org/10.1111/ene.12724
  6. 6.Ramchandren, S., Jaiswal, M., Feldman, E., & Shy, M. (2016). Effect of pain in pediatric inherited neuropathies. Neurology, 87(8), 800-806. https://doi.org/10.1212/WNL.0000000000002939
  7. 7.Sadjadi, R., Reilly, M. M., Shy, M. E., Pareyson, D., Laurá, M., Murphy, S. M., ... & Burns, J. (2014). Psychometrics evaluation of Charcot-Marie-Tooth Neuropathy Score (CMTNSv2) second version, using Rasch analysis. Journal of the Peripheral Nervous System, 19(3), 192-196. https://doi.org/10.1111/jns5.12072
  8. 8.University Hospital, Limoges. (2024). Study of the Relationship Between Clinical and Functional Characteristics of Patients With CMT1A Disease and Their Level of Physical Activity at Home Measured Using Portable Electronic Sensors. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07591779
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