French Registry Study Uses AI Clustering to Define Pulmonary Embolism Phenotypes — Implications for Risk Stratification
247 Health News Editorial
·16 Apr 2026
·3 min read
·clinical-trialsFrench researchers are using AI-driven clustering to identify distinct pulmonary embolism phenotypes in 2,500 patients. This novel approach could revolutionise PE risk stratification and personalised treatment decisions.
Originally reported by ClinicalTrials.gov
References
- 1.Barco, S., Mahmoudpour, S. H., Valerio, L., Klok, F. A., Konstantinides, S. V., Lankeit, M., Brenner, B., Dvir, D., Hirsch, A., Ibrahim, S. A., Jennings, C. S., Jiménez, D., Kaptein, F. H. J., Keller, K., Krievins, D., Lichodziejewska, B., Madridano, O., Meneveau, N., Perrier, A., ... Agnelli, G. (2021). Trends in mortality related to pulmonary embolism in the European Region, 2000-15: Analysis of vital registration data from the WHO Mortality Database. European Respiratory Journal, 57(3), 2002716. https://doi.org/10.1183/13993003.02716-2020
- 2.Carrier, M., Righini, M., Wells, P. S., Perrier, A., Anderson, D. R., Rodger, M. A., Schunemann, H., & Cornuz, J. (2010). Subsegmental pulmonary embolism diagnosed by computed tomography: Incidence and clinical implications. A systematic review and meta-analysis of the management outcome studies. Annals of Internal Medicine, 152(5), 305-315. https://doi.org/10.7326/0003-4819-152-5-201003020-00006
- 3.Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer. (2024). Data Clustering Study With Artificial Intelligence and Phenotyping of Patients Who Presented With Acute Pulmonary Embolism. ClinicalTrials.gov. NCT06183944. https://clinicaltrials.gov/study/NCT06183944
- 4.Jiménez, D., Aujesky, D., Moores, L., Gómez, V., Lobo, J. L., Uresandi, F., Otero, R., Planquette, B., Lecumberri, R., & Yusen, R. D. (2016). Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Archives of Internal Medicine, 170(15), 1383-1389. https://doi.org/10.1001/archinternmed.2010.199
- 5.Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., Bounameaux, H., Huisman, M., King, C. S., Morris, T. A., Sood, N., Stevens, S. M., Vintch, J. R. E., Wells, P., Woller, S. C., & Moores, L. (2016). Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest, 149(2), 315-352. https://doi.org/10.1016/j.chest.2015.11.026
- 6.Klok, F. A., van Kralingen, K. W., van Dijk, A. P., Heyning, F. H., Vliegen, H. W., Kaptein, A. A., & Huisman, M. V. (2018). Prospective cardiopulmonary screening program to detect chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism. Haematologica, 103(6), 1019-1025. https://doi.org/10.3324/haematol.2017.182428
- 7.Konstantinides, S. V., Meyer, G., Becattini, C., Bueno, H., Geersing, G. J., Harjola, V. P., Huisman, M. V., Humbert, M., Jennings, C. S., Jiménez, D., Kucher, N., Lang, I. M., Lankeit, M., Lorusso, R., Mazzolai, L., Meneveau, N., Ní Áinle, F., Prandoni, P., Pruszczyk, P., ... Zamorano, J. L. (2020). 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). European Heart Journal, 41(4), 543-603. https://doi.org/10.1093/eurheartj/ehz405
- 8.Righini, M., Van Es, J., Den Exter, P. L., Roy, P. M., Verschuren, F., Ghuysen, A., Rutschmann, O. T., Sanchez, O., Jaffrelot, M., Trinh-Duc, A., Le Gall, C., Moustafa, F., Principe, A., Van Houten, A. A., Ten Wolde, M., Douma, R. A., Hazelaar, G., Erkens, P. M., Van Kralingen, K. W., ... Perrier, A. (2014). Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: The ADJUST-PE study. JAMA, 311(11), 1117-1124. https://doi.org/10.1001/jama.2014.2135
- 9.Stevens, S. M., Woller, S. C., Baumann Kreuziger, L., Bounameaux, H., Doerschug, K., Geersing, G. J., Huisman, M. V., Kearon, C., King, C. S., Knighton, A. J., Lake, E., Murin, S., Vintch, J. R., Wells, P. S., & Moores, L. K. (2021). Executive summary: Antithrombotic therapy for VTE disease: Second update of the CHEST guideline and expert panel report. Chest, 160(6), 2247-2259. https://doi.org/10.1016/j.chest.2020.08.2064
- 10.Wendelboe, A. M., & Raskob, G. E. (2016). Global burden of thrombosis: Epidemiologic aspects. Circulation Research, 118(9), 1340-1347. https://doi.org/10.1161/CIRCRESAHA.115.306841
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