Health Technology/clinical-trials

French Multicentre Study Tests AI-Based Microbiota Analysis to Predict Necrotising Enterocolitis in Preterm Infants

247 Health News Editorial

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7 Apr 2026

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4 min read

·clinical-trials

French researchers are testing whether AI analysis of faecal microbiota can predict necrotising enterocolitis in preterm infants up to 8 days before clinical onset. The multicentre study aims to recruit 1000 premature babies born before 34 weeks gestation.

Originally reported by ClinicalTrials.gov

References

  1. 1.Battersby, C., Santhalingam, T., Costeloe, K., & Modi, N. (2018). Incidence of neonatal necrotising enterocolitis in high-income countries: a systematic review. Archives of Disease in Childhood-Fetal and Neonatal Edition, 103(2), F182-F189. https://doi.org/10.1136/archdischild-2017-313880
  2. 2.Bell, M. J., Ternberg, J. L., Feigin, R. D., Keating, J. P., Marshall, R., Barton, L., & Brotherton, T. (1978). Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Annals of Surgery, 187(1), 1-7. https://doi.org/10.1097/00000658-197801000-00001
  3. 3.Fitzgibbons, S. C., Ching, Y., Yu, D., Carpenter, J., Kenny, M., Weldon, C., Lillehei, C., Valim, C., Horbar, J. D., & Jaksic, T. (2009). Mortality of necrotizing enterocolitis expressed by birth weight categories. Journal of Pediatric Surgery, 44(6), 1072-1076. https://doi.org/10.1016/j.jpedsurg.2009.02.013
  4. 4.Neu, J., & Walker, W. A. (2011). Necrotizing enterocolitis. New England Journal of Medicine, 364(3), 255-264. https://doi.org/10.1056/NEJMra1005408
  5. 5.Patel, R. M., Kandefer, S., Walsh, M. C., Bell, E. F., Carlo, W. A., Laptook, A. R., Sánchez, P. J., Shankaran, S., Van Meurs, K. P., Ball, M. B., Hale, E. C., Newman, N. S., Das, A., Higgins, R. D., & Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. (2015). Causes and timing of death in extremely premature infants from 2000 through 2011. New England Journal of Medicine, 372(4), 331-340. https://doi.org/10.1056/NEJMoa1403489
  6. 6.University Hospital, Clermont-Ferrand. (2024). Predictive diagnosis of ulcero-necrotizing enterocolitis in premature babies using an artificial intelligence approach based on early analysis of the fecal microbiota. ClinicalTrials.gov. NCT06727877. https://clinicaltrials.gov/study/NCT06727877
  7. 7.Walsh, M. C., & Kliegman, R. M. (1986). Necrotizing enterocolitis: treatment based on staging criteria. Pediatric Clinics of North America, 33(1), 179-201. https://doi.org/10.1016/S0031-3955(16)36251-6
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