Health Technology/clinical-trials

EVAREST Study: Novel Blood and Imaging Biomarkers to Enhance Stress Echocardiography Accuracy in Coronary Disease — What Clinicians Need to Know

247 Health News Editorial

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4 May 2026

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3 min read

·clinical-trials

The EVAREST study is investigating novel blood and imaging biomarkers to improve stress echocardiography accuracy in diagnosing coronary artery disease. This large UK-based observational study of 23,000 participants aims to reduce interpretation variability and enhance diagnostic confidence in cardiac assessment.

Originally reported by ClinicalTrials.gov

References

  1. 1.University of Oxford. (2018). Use of Imaging and Blood Biomarkers to Improve the Diagnostic Accuracy of Cardiac Assessment by Stress Echocardiogram. ClinicalTrials.gov. NCT03674255. https://clinicaltrials.gov/study/NCT03674255
  2. 2.Pellikka, P. A., Nagueh, S. F., Elhendy, A. A., Kuehl, C. A., & Sawada, S. G. (2007). American Society of Echocardiography recommendations for performance, interpretation, and application of stress echocardiography. Journal of the American Society of Echocardiography, 20(9), 1021-1041. https://doi.org/10.1016/j.echo.2007.07.003
  3. 3.Hoffmann, R., Lethen, H., Marwick, T., Arnese, M., Fioretti, P., Pingitore, A., ... & Hanrath, P. (1996). Analysis of interinstitutional observer agreement in interpretation of dobutamine stress echocardiograms. Journal of the American College of Cardiology, 27(2), 330-336. https://doi.org/10.1016/0735-1097(96)00055-5
  4. 4.Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., ... & Windecker, S. (2020). 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal, 41(3), 407-477. https://doi.org/10.1093/eurheartj/ehz425
  5. 5.Marwick, T. H. (2018). Stress echocardiography. Heart, 104(16), 1331-1338. https://doi.org/10.1136/heartjnl-2017-311682
  6. 6.Sicari, R., Nihoyannopoulos, P., Evangelista, A., Kasprzak, J., Lancellotti, P., Poldermans, D., ... & Zamorano, J. L. (2008). Stress echocardiography expert consensus statement. European Journal of Echocardiography, 9(4), 415-437. https://doi.org/10.1016/j.euje.2008.02.001
  7. 7.Australian Institute of Health and Welfare. (2023). Cardiovascular disease in Australia. AIHW. https://www.aihw.gov.au/reports/heart-stroke-vascular-diseases/cardiovascular-health-compendium
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