Health Technology/clinical-trials

DORA Trial: Digital Health-Enabled Study of Synbiotic Milk Powder Effects on Gut Microbiome in Healthy Adults

247 Health News Editorial

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14 May 2026

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4 min read

·clinical-trials

The DORA study combines digital health technology with microbiome research to investigate how synbiotic milk powder affects gut bacteria in healthy adults aged 40-65. This innovative Singapore-based trial uses Apple Watch devices and smartphone apps to monitor participants while they consume the intervention for 28-35 days.

Originally reported by ClinicalTrials.gov

References

  1. 1.Danone Asia Pacific Holdings Pte, Ltd. (2024). DORA - An Exploratory, Interventional Study Using Digital Health Tools and OneBiome to Explore the Impact of the Consumption of Senior Milk Powder Containing Synbiotics on the Gut micRobiome in Healthy Aging Individuals. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07575529
  2. 2.Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018). Inflammaging: a new immune–metabolic viewpoint for age-related diseases. Nature Reviews Endocrinology, 14(10), 576-590. https://doi.org/10.1038/s41574-018-0059-4
  3. 3.Ghosh, T. S., Rampelli, S., Jeffery, I. B., Santoro, A., Neto, M., Capri, M., ... & O'Toole, P. W. (2020). Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries. Gut, 69(7), 1218-1228. https://doi.org/10.1136/gutjnl-2019-319654
  4. 4.Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016). From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell, 165(6), 1332-1345. https://doi.org/10.1016/j.cell.2016.05.041
  5. 5.Morrison, D. J., & Preston, T. (2016). Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes, 7(3), 189-200. https://doi.org/10.1080/19490976.2015.1134082
  6. 6.Steinhubl, S. R., Muse, E. D., & Topol, E. J. (2015). The emerging field of mobile health. Science Translational Medicine, 7(283), 283rv3. https://doi.org/10.1126/scitranslmed.aaa3487
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