Health Technology/clinical-trials

DIGITS Trial Results: Implementation Strategies for Digital Therapeutics in Primary Care Substance Use Disorders — Key Findings for Australian Clinicians

247 Health News Editorial

·

9 Apr 2026

·

3 min read

·clinical-trials

The completed DIGITS trial evaluated implementation strategies for digital therapeutics in primary care substance use disorder treatment, providing crucial insights for healthcare systems adopting evidence-based digital treatments. Results inform optimal approaches for integrating FDA-approved digital therapeutics into routine clinical practice.

Originally reported by ClinicalTrials.gov

References

  1. 1.Christensen, D. R., Landes, S. J., Jackson, L., Marsch, L. A., Mignogna, J., Barve, R., Freitas, D., & Molfenter, T. (2014). Adding an Internet-delivered treatment to an efficacious treatment package for opioid dependence. Journal of Consulting and Clinical Psychology, 82(6), 964-972. https://doi.org/10.1037/a0037496
  2. 2.Curran, G. M., Bauer, M., Mittman, B., Pyne, J. M., & Stetler, C. (2012). Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical Care, 50(3), 217-226. https://doi.org/10.1097/MLR.0b013e3182408812
  3. 3.Damschroder, L. J., Aron, D. C., Keith, R. E., Kirsh, S. R., Alexander, J. A., & Lowery, J. C. (2009). Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implementation Science, 4, 50. https://doi.org/10.1186/1748-5908-4-50
  4. 4.Kaiser Permanente Washington Health Research Institute. (2024). Digital Treatments for Opioids and Other Substance Use Disorders (DIGITS) in Primary Care: A Hybrid Type-III Implementation Trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05160233
  5. 5.Maricich, Y. A., Xiong, X., Gerwien, R., Kvedar, J. C., Schwamm, L. H., Jethwani, K., & Mukamal, K. J. (2021). Real-world evidence for a prescription digital therapeutic to treat opioid use disorder. Current Medical Research and Opinion, 37(4), 613-618. https://doi.org/10.1080/03007995.2021.1907900
  6. 6.Powell, B. J., Waltz, T. J., Chinman, M. J., Damschroder, L. J., Smith, J. L., Matthieu, M. M., Proctor, E. K., & Kirchner, J. E. (2015). A refined compilation of implementation strategies: results from the Expert Recommendations for Implementing Change (ERIC) project. Implementation Science, 10, 21. https://doi.org/10.1186/s13012-015-0209-1
  7. 7.Proctor, E., Silmere, H., Raghavan, R., Hovmand, P., Aarons, G., Bunger, A., Griffey, R., & Hensley, M. (2011). Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Administration and Policy in Mental Health, 38(2), 65-76. https://doi.org/10.1007/s10488-010-0319-7
  8. 8.Saitz, R. (2010). Alcohol screening and brief intervention in primary care: Absence of evidence for efficacy in people with dependence or very heavy drinking. Drug and Alcohol Review, 29(6), 631-640. https://doi.org/10.1111/j.1465-3362.2010.00217.x
  9. 9.Scheirer, M. A., & Dearing, J. W. (2011). An agenda for research on the sustainability of public health programs. American Journal of Public Health, 101(11), 2059-2067. https://doi.org/10.2105/AJPH.2011.300193
  10. 10.Wiltsey Stirman, S., Kimberly, J., Cook, N., Calloway, A., Castro, F., & Charns, M. (2012). The sustainability of new programs and innovations: a review of the empirical literature and recommendations for future research. Implementation Science, 7, 17. https://doi.org/10.1186/1748-5908-7-17
Share:XLinkedIn
2

247 Health News Editorial

247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.

This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service