Health Technology/clinical-trials

Digital Therapeutic Trial Targets Co-Occurring Depression and Cannabis Use Disorder — Novel AMP-C Intervention Under Investigation

247 Health News Editorial

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30 May 2026

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4 min read

·clinical-trials

Massachusetts General Hospital launches AMP-C trial investigating digital therapeutic for co-occurring depression and cannabis use disorder. The study targets reward dysfunction through novel intervention addressing anhedonia in dual diagnosis patients.

Originally reported by ClinicalTrials.gov

References

  1. 1.Massachusetts General Hospital. (2024). AMP-C: A Digital therapeutic for reward dysfunction in co-occurring depression and cannabis use. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06878859
  2. 2.Volkow, N. D., Swanson, J. M., Evins, A. E., DeLisi, L. E., Meier, M. H., Gonzalez, R., ... & Baler, R. (2016). Effects of cannabis use on human behavior, including cognition, motivation, and psychosis: a review. JAMA Psychiatry, 73(3), 292-297. https://doi.org/10.1001/jamapsychiatry.2015.3278
  3. 3.Gowin, J. L., Sloan, M. E., Stangl, B. L., Vatsalya, V., & Ramchandani, V. A. (2017). Vulnerability for alcohol use disorder and rate of alcohol consumption. American Journal of Psychiatry, 174(11), 1094-1101. https://doi.org/10.1176/appi.ajp.2017.16101180
  4. 4.Hasin, D. S., Saha, T. D., Kerridge, B. T., Goldstein, R. B., Chou, S. P., Zhang, H., ... & Grant, B. F. (2015). Prevalence of marijuana use disorders in the United States between 2001-2002 and 2012-2013. JAMA Psychiatry, 72(12), 1235-1242. https://doi.org/10.1001/jamapsychiatry.2015.1858
  5. 5.Lev-Ran, S., Roerecke, M., Le Foll, B., George, T. P., McKenzie, K., & Rehm, J. (2014). The association between cannabis use and depression: a systematic review and meta-analysis of longitudinal studies. Psychological Medicine, 44(4), 797-810. https://doi.org/10.1017/S0033291713001438
  6. 6.World Health Organization. (2023). Depressive disorder (depression). WHO Fact Sheets. https://www.who.int/news-room/fact-sheets/detail/depression
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