Digital Therapeutic Trial Targets Co-Occurring Depression and Cannabis Use Disorder — Novel AMP-C Intervention Under Investigation
247 Health News Editorial
·30 May 2026
·4 min read
·clinical-trialsMassachusetts General Hospital launches AMP-C trial investigating digital therapeutic for co-occurring depression and cannabis use disorder. The study targets reward dysfunction through novel intervention addressing anhedonia in dual diagnosis patients.
Originally reported by ClinicalTrials.gov
References
- 1.Massachusetts General Hospital. (2024). AMP-C: A Digital therapeutic for reward dysfunction in co-occurring depression and cannabis use. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06878859
- 2.Volkow, N. D., Swanson, J. M., Evins, A. E., DeLisi, L. E., Meier, M. H., Gonzalez, R., ... & Baler, R. (2016). Effects of cannabis use on human behavior, including cognition, motivation, and psychosis: a review. JAMA Psychiatry, 73(3), 292-297. https://doi.org/10.1001/jamapsychiatry.2015.3278
- 3.Gowin, J. L., Sloan, M. E., Stangl, B. L., Vatsalya, V., & Ramchandani, V. A. (2017). Vulnerability for alcohol use disorder and rate of alcohol consumption. American Journal of Psychiatry, 174(11), 1094-1101. https://doi.org/10.1176/appi.ajp.2017.16101180
- 4.Hasin, D. S., Saha, T. D., Kerridge, B. T., Goldstein, R. B., Chou, S. P., Zhang, H., ... & Grant, B. F. (2015). Prevalence of marijuana use disorders in the United States between 2001-2002 and 2012-2013. JAMA Psychiatry, 72(12), 1235-1242. https://doi.org/10.1001/jamapsychiatry.2015.1858
- 5.Lev-Ran, S., Roerecke, M., Le Foll, B., George, T. P., McKenzie, K., & Rehm, J. (2014). The association between cannabis use and depression: a systematic review and meta-analysis of longitudinal studies. Psychological Medicine, 44(4), 797-810. https://doi.org/10.1017/S0033291713001438
- 6.World Health Organization. (2023). Depressive disorder (depression). WHO Fact Sheets. https://www.who.int/news-room/fact-sheets/detail/depression
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247 Health News Editorial
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