Digital Therapeutic Shows Promise for PTSD Nightmares: NightWare System Completes Phase III Trial in Military Veterans
247 Health News Editorial
·16 Apr 2026
·4 min read
·clinical-trialsThe completed TNT/NW trial investigated NightWare's digital therapeutic system in 270 military veterans with PTSD-related nightmares. This innovative iPhone and Apple Watch-based intervention aims to interrupt nightmares without fully awakening patients, potentially revolutionising treatment for this challenging condition.
Originally reported by ClinicalTrials.gov
References
- 1.Babson, K. A., & Feldner, M. T. (2010). Temporal relations between sleep problems and both traumatic event exposure and PTSD: a critical review of the empirical literature. Journal of Anxiety Disorders, 24(1), 1-15. https://doi.org/10.1016/j.janxdis.2010.05.001
- 2.Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Research, 28(2), 193-213. https://doi.org/10.1016/0165-1781(89)90047-4
- 3.Germain, A., Buysse, D. J., & Nofzinger, E. (2008). Sleep-specific mechanisms underlying posttraumatic stress disorder: integrative review and neurobiological hypotheses. Sleep Medicine Reviews, 12(3), 185-195. https://doi.org/10.1016/j.smrv.2007.09.003
- 4.Krakow, B., & Zadra, A. (2006). Clinical management of chronic nightmares: imagery rehearsal therapy. Behavioral Sleep Medicine, 4(1), 45-70. https://doi.org/10.1207/s15402010bsm0401_4
- 5.Miller, K. E., Brownlow, J. A., Woodward, S., & Gehrman, P. R. (2017). Sleep and dreaming in posttraumatic stress disorder. Current Psychiatry Reports, 19(10), 71. https://doi.org/10.1007/s11920-017-0827-1
- 6.NightWare. (2024). TNT/NW: Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT04040387
- 7.Raskind, M. A., Peterson, K., Williams, T., Hoff, D. J., Hart, K., Holmes, H., ... & McFall, M. E. (2013). A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan. American Journal of Psychiatry, 170(9), 1003-1010. https://doi.org/10.1176/appi.ajp.2012.12081133
- 8.Therapeutic Goods Administration. (2023). Software as Medical Device: Guidance for industry. TGA Guidelines. https://www.tga.gov.au/resources/resource/guidance/software-medical-device-guidance-industry
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247 Health News Editorial
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