Health Technology/clinical-trials

Digital Health Pilot Study Evaluates Virtual Mind-Body Intervention for Radiation-Induced Fatigue in Breast Cancer — Implementation Outcomes Focus

247 Health News Editorial

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10 June 2026

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4 min read

·clinical-trials

The PRO-ACTIVE pilot study evaluates a virtual mind-body intervention for managing radiation-induced fatigue in breast cancer patients. This implementation science study focuses on feasibility and acceptability of digital health delivery for evidence-based symptom management.

Originally reported by ClinicalTrials.gov

References

  1. 1.Berger, A. M., Mooney, K., Alvarez-Perez, A., Breitbart, W. S., Carpenter, K. M., Cella, D., ... & Smith, C. (2015). Cancer-related fatigue, version 2.2015. Journal of the National Comprehensive Cancer Network, 13(8), 1012-1039. https://doi.org/10.6004/jnccn.2015.0085
  2. 2.Bender, J. L., Yue, R. Y., To, M. J., Deacken, L., & Jadad, A. R. (2013). A lot of action, but not in the right direction: systematic review and content analysis of smartphone applications for the prevention, detection, and management of cancer. Journal of Medical Internet Research, 15(12), e2661. https://doi.org/10.2196/jmir.2661
  3. 3.Bower, J. E. (2014). Cancer-related fatigue—mechanisms, risk factors, and treatments. Nature Reviews Clinical Oncology, 11(10), 597-609. https://doi.org/10.1038/nrclinonc.2014.127
  4. 4.Eldridge, S. M., Lancaster, G. A., Campbell, M. J., Thabane, L., Hopewell, S., Coleman, C. L., & Bond, C. M. (2016). Defining feasibility and pilot studies in preparation for randomised controlled trials: development of a conceptual framework. PLoS One, 11(3), e0150205. https://doi.org/10.1371/journal.pone.0150205
  5. 5.Mustian, K. M., Alfano, C. M., Heckler, C., Kleckner, A. S., Kleckner, I. R., Leach, C. R., ... & Miller, S. M. (2017). Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: A meta-analysis. JAMA Oncology, 3(7), 961-968. https://doi.org/10.1001/jamaoncol.2016.6914
  6. 6.Proctor, E., Silmere, H., Raghavan, R., Hovmand, P., Aarons, G., Bunger, A., ... & Hensley, M. (2011). Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Administration and Policy in Mental Health, 38(2), 65-76. https://doi.org/10.1007/s10488-010-0319-7
  7. 7.University of Washington. (2025). Multicenter Pilot Study: Leveraging Digital Health to Promote Evidence-Based Physical Activity to Improve Symptoms Among Patients Undergoing Radiation for Breast Cancer (PRO-ACTIVE). ClinicalTrials.gov Identifier: NCT06772181. https://clinicaltrials.gov/study/NCT06772181
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247 Health News Editorial

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