Health Technology/clinical-trials

Digital Health Intervention Trial Targets Learning Disparities in Paediatric Cancer Survivors — Novel eHealth Platform Shows Promise

247 Health News Editorial

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16 Apr 2026

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3 min read

·clinical-trials

A groundbreaking US trial examines whether digital health interventions can address learning difficulties in children who have survived acute leukaemia and lymphoblastic lymphoma. The study targets neurocognitive late effects affecting up to 40% of paediatric cancer survivors.

Originally reported by ClinicalTrials.gov

References

  1. 1.Campbell, L. K., Scaduto, M., Sharp, W., Dufton, L., Van Slyke, D., Whitlock, J. A., & Compas, B. E. (2007). A meta-analysis of the neurocognitive sequelae of treatment for childhood acute lymphoblastic leukemia. Pediatric Blood & Cancer, 49(1), 65-73. https://doi.org/10.1002/pbc.21110
  2. 2.Cheung, Y. T., & Krull, K. R. (2015). Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols. Current Neurology and Neuroscience Reports, 15(8), 575. https://doi.org/10.1007/s11910-015-0575-9
  3. 3.City of Hope Medical Center. (2024). Leveraging Digital Health Solutions to Reduce Learning and Functional Disparities in Children With Cancer. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05428176
  4. 4.Krull, K. R., Hardy, K. K., Kahalley, L. S., Schuitema, I., & Kesler, S. R. (2018). Neurocognitive outcomes and interventions in long-term survivors of childhood cancer. Journal of Clinical Oncology, 36(21), 2181-2189. https://doi.org/10.1200/JCO.2017.76.4696
  5. 5.Mitby, P. A., Robison, L. L., Whitton, J. A., Zevon, M. A., Gibbs, I. C., Tersak, J. M., ... & Mertens, A. C. (2003). Utilization of special education services and educational attainment among long-term survivors of childhood cancer. Cancer, 98(6), 1191-1200. https://doi.org/10.1002/cncr.11660
  6. 6.Mulhern, R. K., & Butler, R. W. (2004). Neurocognitive sequelae of childhood cancers and their treatment. Pediatric Rehabilitation, 7(1), 1-14. https://doi.org/10.1080/13638490310001655528
  7. 7.Peterson, C. C., Johnson, C. E., Ramirez, L. Y., Huestis, S., Pai, A. L., Demaree, H. A., & Drotar, D. (2008). A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia. Pediatric Blood & Cancer, 51(1), 99-104. https://doi.org/10.1002/pbc.21544
  8. 8.Schulte, F., & Barrera, M. (2010). Social competence in childhood brain tumor survivors: a comprehensive review. Supportive Care in Cancer, 18(12), 1529-1543. https://doi.org/10.1007/s00520-010-0963-1
  9. 9.Varni, J. W., Burwinkle, T. M., Katz, E. R., Meeske, K., & Dickinson, P. (2002). The PedsQL in pediatric cancer: reliability and validity of the Pediatric Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module. Cancer, 94(7), 2090-2106. https://doi.org/10.1002/cncr.10298
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247 Health News Editorial

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