Health Technology/clinical-trials

Digital Exercise Intervention Trial Opens for Fontan Patients: Home-Based Program Targets Fitness Deficits in Complex Congenital Heart Disease

247 Health News Editorial

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15 Apr 2026

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4 min read

·clinical-trials

New randomised trial tests home-based digital exercise intervention for children with Fontan circulation. The study aims to improve physical fitness and activity levels in this vulnerable congenital heart disease population through structured aerobic and resistance training delivered via digital platforms.

Originally reported by ClinicalTrials.gov

References

  1. 1.Banks, L., Rosenthal, S., Manlhiot, C., Fan, C. P. S., McKillop, A., Longmuir, P. E., & McCrindle, B. W. (2017). Exercise training in pediatric patients with congenital heart disease: a systematic review. Frontiers in Cardiovascular Medicine, 4, 57. https://doi.org/10.3389/fcvm.2017.00057
  2. 2.Children's Hospital of Philadelphia. (2024). Home-based, Digital Intervention to Increase Physical Activity in Patients With the Fontan Circulation. ClinicalTrials.gov. NCT06918795. https://clinicaltrials.gov/study/NCT06918795
  3. 3.Cordina, R., O'Meagher, S., Gould, H., Rae, C., Kemp, G., Pasco, J. A., ... & Celermajer, D. S. (2013). Skeletal muscle abnormalities and exercise capacity in adults with a Fontan circulation. Heart, 99(20), 1530-1534. https://doi.org/10.1136/heartjnl-2013-304249
  4. 4.Dulfer, K., Helbing, W. A., Duppen, N., & Utens, E. M. (2014). Associations between exercise capacity, physical activity, and psychosocial functioning in children with congenital heart disease: a systematic review. European Journal of Preventive Cardiology, 21(10), 1200-1215. https://doi.org/10.1177/2047487313494030
  5. 5.Hedlund, E. R., Lundell, B., Villard, L., & Sjöberg, G. (2018). Reduced physical exercise capacity in school-aged children with congenital heart disease is related to parental anxiety and reduced physical activity. Cardiology in the Young, 28(9), 1088-1095. https://doi.org/10.1017/S1047951118000963
  6. 6.Khairy, P., Fernandes, S. M., Mayer Jr, J. E., Triedman, J. K., Walsh, E. P., Lock, J. E., & Landzberg, M. J. (2008). Long-term survival, modes of death, and predictors of mortality in patients with Fontan surgery. Circulation, 117(1), 85-92. https://doi.org/10.1161/CIRCULATIONAHA.107.738559
  7. 7.Rychik, J., Atz, A. M., Celermajer, D. S., Deal, B. J., Gatzoulis, M. A., Gewillig, M. H., ... & Warnes, C. A. (2019). Evaluation and management of the child and adult with Fontan circulation: a scientific statement from the American Heart Association. Circulation, 140(6), e234-e284. https://doi.org/10.1161/CIR.0000000000000696
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247 Health News Editorial

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