Health Technology/clinical-trials

DIANA Study: Machine Learning to Predict Epidural Anaesthetic Dosing in Labour — Personalised Pain Management on the Horizon

247 Health News Editorial

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15 June 2026

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4 min read

·clinical-trials

The DIANA study aims to revolutionise epidural analgesia by developing machine-learning algorithms to predict individual local anaesthetic requirements during labour. This groundbreaking research could personalise pain management for 12,500 parturients, moving beyond one-size-fits-all dosing protocols.

Originally reported by ClinicalTrials.gov

References

  1. 1.Anim-Somuah, M., Smyth, R. M., Cyna, A. M., & Cuthbert, A. (2018). Epidural versus non-epidural or no analgesia for pain management in labour. Cochrane Database of Systematic Reviews, 5(5), CD000331. https://doi.org/10.1002/14651858.CD000331.pub4
  2. 2.Australian and New Zealand College of Anaesthetists. (2024). Guidelines on obstetric anaesthesia and analgesia. ANZCA. https://www.anzca.edu.au/safety-advocacy/standards-of-practice/guidelines
  3. 3.Australian Institute of Health and Welfare. (2023). Australia's mothers and babies data visualisations. AIHW. https://www.aihw.gov.au/reports/mothers-babies/australias-mothers-babies-data-visualisations
  4. 4.Beilin, Y., Bodian, C. A., Weiser, J., Hossain, S., Arnold, I., Feierman, D. E., Martin, G., Holzman, I., & Silverman, N. (2005). Effect of labor epidural analgesia with and without fentanyl on infant breast-feeding. Anesthesiology, 103(6), 1211-1217. https://doi.org/10.1097/00000542-200511000-00029
  5. 5.Carvalho, B., & Butwick, A. J. (2017). Postcesarean delivery analgesia. Best Practice & Research Clinical Anaesthesiology, 31(1), 69-79. https://doi.org/10.1016/j.bpa.2017.01.003
  6. 6.Comparative Obstetric Mobile Epidural Trial (COMET) Study Group UK. (2001). Effect of low-dose mobile versus traditional epidural techniques on mode of delivery: a randomised controlled trial. The Lancet, 358(9275), 19-23. https://doi.org/10.1016/S0140-6736(00)04834-5
  7. 7.Fondazione Policlinico Universitario Agostino Gemelli IRCCS. (2024). Prediction of Local Anaesthetic Dosing During Labour Epidural Analgesia: a Machine-learning Approach. The DIANA Study. ClinicalTrials.gov Identifier: NCT07614516. https://clinicaltrials.gov/study/NCT07614516
  8. 8.Gambling, D., Berkowitz, J., Farrell, T. R., Pue, A., & Shay, D. (2013). A randomized controlled comparison of epidural analgesia and combined spinal-epidural analgesia in a private practice setting. Anesthesia & Analgesia, 116(1), 133-144. https://doi.org/10.1213/ANE.0b013e31828f2b69
  9. 9.Halpern, S. H., & Carvalho, B. (2009). Patient-controlled epidural analgesia for labor. Anesthesia & Analgesia, 108(3), 921-928. https://doi.org/10.1213/ane.0b013e3181a30b63
  10. 10.Hess, P. E., Pratt, S. D., Lucas, T. P., Miller, C. G., Corbett, T., Oriol, N., & Sarna, M. C. (2001). Predictors of breakthrough pain during labor epidural analgesia. Anesthesia & Analgesia, 93(1), 114-118. https://doi.org/10.1097/00000539-200107000-00016
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247 Health News Editorial

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