Health Technology/clinical-trials

Decision Aid Trial for Medullary Thyroid Cancer: Empowering Patients and Clinicians in Complex Treatment Choices

247 Health News Editorial

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18 July 2026

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5 min read

·clinical-trials

MD Anderson Cancer Center is recruiting patients, caregivers, and clinicians for a landmark study developing a validated decision aid for medullary thyroid cancer — targeting the high-stakes choices around initiating or stopping kinase inhibitors, enrolling in trials, or continuing active surveillance. With MTC management growing more complex in the era of selective RET inhibitors, this tool could transform shared decision-making for one of endocrinology's most challenging malignancies.

Originally reported by ClinicalTrials.gov

References

  1. 1.MD Anderson Cancer Center. (2019). Designing a decision aid to help people with medullary thyroid cancer make decisions with their doctors about whether to start or stop new drugs, enroll in clinical trials, or continue with active surveillance (NCT03892993). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT03892993
  2. 2.Wells, S. A., Asa, S. L., Dralle, H., Elisei, R., Evans, D. B., Gagel, R. F., Lee, N., Machens, A., Moley, J. F., Pacini, F., Raue, F., Frank-Raue, K., Robinson, B., Rosenthal, M. S., Santoro, M., Schlumberger, M., Shah, M., & Waguespack, S. G. (2015). Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid, 25(6), 567–610. https://doi.org/10.1089/thy.2014.0335
  3. 3.Coulter, A., Stilwell, D., Kryworuchko, J., Mullen, P. D., Ng, C. J., & van der Weijden, T. (2013). A systematic development process for patient decision aids. BMC Medical Informatics and Decision Making, 13(Suppl 2), S2. https://doi.org/10.1186/1472-6947-13-S2-S2
  4. 4.Stacey, D., Légaré, F., Lewis, K., Barry, M. J., Bennett, C. L., Eden, K. B., Holmes-Rovner, M., Llewellyn-Thomas, H., Lyddiatt, A., Thomson, R., & Trevena, L. (2017). Decision aids for people facing health treatment or screening decisions. Cochrane Database of Systematic Reviews, 4, CD001431. https://doi.org/10.1002/14651858.CD001431.pub5
  5. 5.Wirth, L. J., Sherman, E., Robinson, B., Solomon, B., Kang, H., Lorch, J., Worden, F., Brose, M., Patel, J., Leboulleux, S., Godbert, Y., Barlesi, F., Morris, J. C., Owonikoko, T. K., Tan, D. S. W., Gautschi, O., Weiss, J., de la Fouchardière, C., Burkard, M. E., … Drilon, A. (2020). Efficacy of selpercatinib in RET-altered thyroid cancers. New England Journal of Medicine, 383(9), 825–835. https://doi.org/10.1056/NEJMoa2005651
  6. 6.Schlumberger, M., Elisei, R., Müller, S., Schöffski, P., Brose, M., Shah, M., Licitra, L., Krajewska, J., Kreissl, M. C., Niederle, B., Cohen, E. E. W., Wirth, L. J., Ali, H., Clary, D. O., Yaron, Y., Mangeshkar, M., Bencardino, K., & Tahara, M. (2017). Overall survival analysis of EXAM, a phase III trial of cabozantinib in patients with radiographically progressive medullary thyroid carcinoma. Annals of Oncology, 28(11), 2813–2819. https://doi.org/10.1093/annonc/mdx479
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247 Health News Editorial

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