Health Technology/clinical-trials

Completed Trial: Cognitive Therapy, Mindfulness, and Behavioural Activation Compared for Opioid Reduction in Chronic Musculoskeletal Pain — Mechanisms and Matching Explored

247 Health News Editorial

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12 July 2026

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5 min read

·clinical-trials

A completed University of Washington trial has investigated the mechanisms by which Cognitive Therapy, Mindfulness Meditation, and Behavioural Activation reduce opioid use in adults with chronic musculoskeletal pain. With results anticipated in peer-reviewed literature, the findings could reshape how clinicians match patients to psychosocial pain interventions and support evidence-based opioid deprescribing strategies.

Originally reported by ClinicalTrials.gov

References

  1. 1.University of Washington. (2019). Mechanisms of psychosocial treatments on opioid use in chronic pain (NCT03916276). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT03916276
  2. 2.Vowles, K. E., Witkiewitz, K., Levell, J., Sowden, G., & Ashworth, J. (2017). Are reductions in pain intensity and pain-related distress necessary? An analysis of within-treatment change trajectories in relation to improved functioning following interdisciplinary acceptance and commitment therapy for adults with chronic pain. Journal of Consulting and Clinical Psychology, 85(2), 87–98. https://doi.org/10.1037/ccp0000195
  3. 3.Dowell, D., Ragan, K. R., Jones, C. M., Baldwin, G. T., & Chou, R. (2022). CDC clinical practice guideline for prescribing opioids for pain — United States, 2022. MMWR Recommendations and Reports, 71(3), 1–95. https://doi.org/10.15585/mmwr.rr7103a1
  4. 4.Ehde, D. M., Dillworth, T. M., & Turner, J. A. (2014). Cognitive-behavioral therapy for individuals with chronic pain: Efficacy, innovations, and directions for research. American Psychologist, 69(2), 153–166. https://doi.org/10.1037/a0035747
  5. 5.Vos, T., Lim, S. S., Abbafati, C., Abbas, K. M., Abbasi, M., Abbasifard, M., & Murray, C. J. L. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10258), 1204–1222. https://doi.org/10.1016/S0140-6736(20)30925-9
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247 Health News Editorial

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