Completed Trial: AI-Assisted Colonoscopy Plus Endocuff Device Shows Promise for Enhanced Adenoma Detection
247 Health News Editorial
·24 Apr 2026
·3 min read
·clinical-trialsA completed 1,726-patient trial investigated whether combining AI-assisted colonoscopy with mucosal exposure devices improves adenoma detection rates. Results could reshape colonoscopy quality standards and technology adoption in colorectal cancer screening programs.
Originally reported by ClinicalTrials.gov
References
- 1.Aziz, M., Fatima, R., Dong, C., Lee-Smith, W., & Nawras, A. (2020). The impact of deep convolutional neural network-based artificial intelligence on colonoscopy outcomes: a systematic review with meta-analysis. Journal of Gastroenterology and Hepatology, 35(9), 1676-1683. https://doi.org/10.1111/jgh.14777
- 2.Chinese University of Hong Kong. (2024). Combination of Artificial Intelligence (ENDOAID) and Mucosal Exposure Device (ENDOCUFF) to Enhance Colorectal Neoplasia Detection: a Randomized Controlled Trial. ClinicalTrials.gov. NCT05414448. https://clinicaltrials.gov/study/NCT05414448
- 3.Corley, D. A., Jensen, C. D., Marks, A. R., Zhao, W. K., Lee, J. K., Doubeni, C. A., Zauber, A. G., de Boer, J., Fireman, B. H., Schottinger, J. E., Quinn, V. P., Ghai, N. R., Levin, T. R., & Quesenberry, C. P. (2014). Adenoma detection rate and risk of colorectal cancer and death. New England Journal of Medicine, 370(14), 1298-1306. https://doi.org/10.1056/NEJMoa1309086
- 4.Hassan, C., Spadaccini, M., Iannone, A., Maselli, R., Jovani, M., Chandrasekar, V. T., Antonelli, G., Yu, H., Areia, M., Dinis-Ribeiro, M., Bhandari, P., Sharma, P., Rex, D. K., & Repici, A. (2021). Performance of artificial intelligence in colonoscopy for adenoma and polyp detection: a systematic review and meta-analysis. Gastrointestinal Endoscopy, 93(1), 77-85. https://doi.org/10.1016/j.gie.2020.06.059
- 5.Ngu, W. S., Bevan, R., Tsiamoulos, Z. P., Bassett, P., Hoare, J., Rutter, M. D., Clifford, G., Totton, N., Lee, M., Ramadas, A., Silcock, J., Painter, J., Nolan, D., Tripathi, D., Tam, W., Hancock, H., Dunckley, P., Thomas-Gibson, S., Saunders, B. P., & Rees, C. J. (2019). Improved adenoma detection with Endocuff Vision: the ADENOMA randomised controlled trial. Gut, 68(2), 280-288. https://doi.org/10.1136/gutjnl-2018-317010
- 6.van Rijn, J. C., Reitsma, J. B., Stoker, J., Bossuyt, P. M., van Deventer, S. J., & Dekker, E. (2006). Polyp miss rate determined by tandem colonoscopy: a systematic review. American Journal of Gastroenterology, 101(2), 343-350. https://doi.org/10.1111/j.1572-0241.2006.00390.x
- 7.Wang, P., Berzin, T. M., Glissen Brown, J. R., Bharadwaj, S., Becq, A., Xiao, X., Liu, P., Li, L., Song, Y., Zhang, D., Li, Y., Xu, G., Tu, M., & Liu, X. (2019). Real-time automatic detection system increases colonoscopic polyp and adenoma detection rates: a prospective randomised controlled study. Gut, 68(10), 1813-1819. https://doi.org/10.1136/gutjnl-2018-317500
- 8.Williet, N., Tournier, Q., Vernet, C., Dumas, O., Rinaldi, L., Roblin, X., & Phelip, J. M. (2018). Effect of Endocuff-assisted colonoscopy on adenoma detection rate: meta-analysis of randomized controlled trials. Endoscopy, 50(9), 846-860. https://doi.org/10.1055/s-0043-125207
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