Health Technology/clinical-trials

Completed Pilot RCT: IMB-Guided Digital Intervention Boosts HIV Self-Testing and PrEP Uptake in Young Men Who Have Sex with Men

247 Health News Editorial

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9 May 2026

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4 min read

·clinical-trials

A completed US pilot RCT demonstrated that theory-based digital interventions can effectively promote HIV self-testing and PrEP uptake among young men who have sex with men. The study's IMB model approach offers insights for Australian HIV prevention strategies.

Originally reported by ClinicalTrials.gov

References

  1. 1.Australian Government Department of Health. (2022). Pre-exposure prophylaxis (PrEP) for HIV prevention. Australian Government Health Guidelines. https://www.health.gov.au/topics/sexual-health/sexually-transmissible-infections-stis/hiv/pre-exposure-prophylaxis-prep-for-hiv-prevention
  2. 2.Bauermeister, J. A., Tingler, R. C., Demers, M., Harper, G. W., Santana, M., & Horvath, K. J. (2017). A multilevel tailored web app-based intervention for linking young men who have sex with men to quality care (Get Connected): Protocol for a randomized controlled trial. JMIR Research Protocols, 6(12), e8444. https://doi.org/10.2196/resprot.8444
  3. 3.Centers for Disease Control and Prevention. (2021). Preexposure prophylaxis for the prevention of HIV infection in the United States—2021 Update: A clinical practice guideline. CDC Guidelines. https://www.cdc.gov/hiv/pdf/risk/prep/cdc-hiv-prep-guidelines-2021.pdf
  4. 4.Fisher, J. D., & Fisher, W. A. (2000). Theoretical approaches to individual-level change in HIV risk behavior. In Handbook of HIV prevention (pp. 3-55). Springer. https://doi.org/10.1007/978-1-4615-4137-0_1
  5. 5.Golub, S. A., Fikslin, R. A., Starbuck, L., & Klein, A. (2018). From efficacy to effectiveness: Facilitating HIV preexposure prophylaxis uptake and adherence among young men who have sex with men and transgender women. AIDS, 32(Suppl 1), S25-S33. https://doi.org/10.1097/QAD.0000000000001701
  6. 6.Hess, K. L., Hu, X., Lansky, A., Mermin, J., & Hall, H. I. (2017). Lifetime risk of a diagnosis of HIV infection in the United States. Annals of Epidemiology, 27(4), 238-243. https://doi.org/10.1016/j.annepidem.2017.02.003
  7. 7.Johnson, C. C., Kennedy, C., Fonner, V., Siegfried, N., Figueroa, C., Dalal, S., ... & Baggaley, R. (2017). Examining the effects of HIV self-testing compared to standard HIV testing services: A systematic review and meta-analysis. Journal of the International AIDS Society, 20(1), 21594. https://doi.org/10.7448/IAS.20.1.21594
  8. 8.Medical College of Wisconsin. (2024). Optimizing an IMB-guided Intervention to Support HIV Self-testing and PrEP Uptake Among YMSM: A Pilot Randomized Controlled Trial. ClinicalTrials.gov. NCT04865341. https://clinicaltrials.gov/study/NCT04865341
  9. 9.Mustanski, B., Macapagal, K., Thomann, M., Feinstein, B. A., Newcomb, M. E., & Whitton, S. W. (2020). Geographic and individual associations with PrEP stigma: Results from the RADAR cohort of diverse young men who have sex with men and transgender women. AIDS and Behavior, 24(12), 3293-3304. https://doi.org/10.1007/s10461-020-02952-x
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247 Health News Editorial

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