Completed Multicentre Trial: AI-Assisted Fluid Management vs Standard Care in High-Risk Abdominal Surgery — Major Outcomes Data Pending
247 Health News Editorial
·16 June 2026
·3 min read
·clinical-trialsA completed international trial of 2,007 high-risk surgical patients evaluated AI-assisted fluid management versus standard care in major abdominal surgery. Results pending in 2026 could transform perioperative fluid therapy protocols.
Originally reported by ClinicalTrials.gov
References
- 1.Assistance Publique - Hôpitaux de Paris. (2023). Personalized fluid administration using an AFM system for goal directed fluid therapy on postoperative outcome in high-risk patients undergoing high-risk abdominal surgery: A multicenter stepped-wedge, cluster-randomized clinical trial. ClinicalTrials.gov. NCT06011187. https://clinicaltrials.gov/study/NCT06011187
- 2.Cecconi, M., Hofer, C., Teboul, J. L., Pettila, V., Wilkman, E., Molnar, Z., Della Rocca, G., Aldecoa, C., Artigas, A., Jog, S., Sander, M., Spies, C., Lefrant, J. Y., De Backer, D., & FENICE Investigators and the ESICM Trial Group. (2015). Fluid challenges in intensive care: The FENICE study. Intensive Care Medicine, 41(9), 1529-1537. https://doi.org/10.1007/s00134-015-3850-x
- 3.Hemming, K., Haines, T. P., Chilton, P. J., Girling, A. J., & Lilford, R. J. (2015). The stepped wedge cluster randomised trial: Rationale, design, analysis, and reporting. BMJ, 350, h391. https://doi.org/10.1136/bmj.h391
- 4.Myles, P. S., Bellomo, R., Corcoran, T., Forbes, A., Peyton, P., Story, D., Christophi, C., Leslie, K., McGuinness, S., Parke, R., Serpell, J., Chan, M. T. V., Painter, T., McCluskey, S., Minto, G., Boyd, S., & Australian and New Zealand College of Anaesthetists Clinical Trials Network and the Australian and New Zealand Intensive Care Society Clinical Trials Group. (2018). Restrictive versus liberal fluid therapy for major abdominal surgery. New England Journal of Medicine, 378(24), 2263-2274. https://doi.org/10.1056/NEJMoa1801601
- 5.Pearse, R. M., Harrison, D. A., MacDonald, N., Gillies, M. A., Blunt, M., Ackland, G., Grocott, M. P. W., Ahern, A., Griggs, K., Scott, R., Hinds, C., Rowan, K., & OPTIMISE Study Group. (2014). Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: A randomized clinical trial and systematic review. JAMA, 311(21), 2181-2190. https://doi.org/10.1001/jama.2014.5305
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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