Closed-Loop Brain Interchange System Targets High-Frequency Oscillations Before Seizure Onset in Drug-Resistant Epilepsy — A First-Look at Pre-Emptive Neurostimulation

References

1. 1.Mayo Clinic. (2022). Acute recording of stereotyped high-frequency oscillations with a closed-loop Brain Interchange system in drug-resistant epilepsy (NCT05439655). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05439655
2. 2.Bergey, G. K., Morrell, M. J., Mizrahi, E. M., Goldman, A., King-Stephens, D., Nair, D., Srinivasan, S., Jobst, B., Gross, R. E., Shields, D. C., Barkley, G., Salanova, V., Olejniczak, P., Cole, A., Cash, S. S., Noe, K., Wharen, R., Worrell, G., Murro, A. M., … Heck, C. (2015). Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Neurology, 84(8), 810–817. https://doi.org/10.1212/WNL.0000000000001280
3. 3.Jacobs, J., Staba, R., Asano, E., Otsubo, H., Wu, J. Y., Zijlmans, M., Mohamed, I., Kahane, P., Dubeau, F., Navarro, V., & Gotman, J. (2012). High-frequency oscillations (HFOs) in clinical epilepsy. Progress in Neurobiology, 98(3), 302–315. https://doi.org/10.1016/j.pneurobio.2011.09.004
4. 4.Kwan, P., Arzimanoglou, A., Berg, A. T., Brodie, M. J., Allen Hauser, W., Mathern, G., Moshé, S. L., Perucca, E., Wiebe, S., & French, J. (2010). Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 51(6), 1069–1077. https://doi.org/10.1111/j.1528-1167.2009.02397.x
5. 5.Worrell, G. A., Gardner, A. B., Stead, S. M., Hu, S., Goerss, S., Cascino, G. J., Meyer, F. B., Marsh, R., & Litt, B. (2008). High-frequency oscillations in human temporal lobe: Simultaneous microwire and clinical macroelectrode recordings. Brain, 131(4), 928–937. https://doi.org/10.1093/brain/awn006
6. 6.Zijlmans, M., Jiruska, P., Zelmann, R., Leijten, F. S. S., Jefferys, J. G. R., & Gotman, J. (2012). High-frequency oscillations as a new biomarker in epilepsy. Annals of Neurology, 71(2), 169–178. https://doi.org/10.1002/ana.22548