Health Technology/clinical-trials

Clinical Decision Support Trial Targets Naloxone Co-prescribing in High-Risk Opioid Patients — Implementation Study Results Due 2025

247 Health News Editorial

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23 May 2026

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3 min read

·clinical-trials

Large-scale US study evaluating clinical decision support alerts to increase naloxone co-prescribing with high-risk opioid prescriptions. Results from 200,000 participants expected 2025, with implications for Australian healthcare systems.

Originally reported by ClinicalTrials.gov

References

  1. 1.Bright, T. J., Wong, A., Dhurjati, R., Bristow, E., Bastian, L., Coeytaux, R. R., Samsa, G. P., Hasselblad, V., Williams, J. W., Musty, M. D., Wing, L., Kendrick, A. S., Sanders, G. D., & Lobach, D. (2012). Effect of clinical decision-support systems: a systematic review. Annals of Internal Medicine, 157(1), 29-43. https://doi.org/10.7326/0003-4819-157-1-201207030-00450
  2. 2.Coffin, P. O., & Sullivan, S. D. (2013). Cost-effectiveness of distributing naloxone to heroin users for lay overdose reversal. Annals of Internal Medicine, 158(1), 1-9. https://doi.org/10.7326/0003-4819-158-1-201301010-00003
  3. 3.Dowell, D., Ragan, K. R., Jones, C. M., Baldwin, G. T., & Chou, R. (2022). CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022. MMWR Recommendations and Reports, 71(3), 1-95. https://doi.org/10.15585/mmwr.rr7103a1
  4. 4.McDonald, R., & Strang, J. (2016). Are take-home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria. Addiction, 111(7), 1177-1187. https://doi.org/10.1111/add.13326
  5. 5.Nielsen, S., Peacock, A., Lintzeris, N., Bruno, R., Larance, B., & Degenhardt, L. (2018). Knowledge of opioid overdose and attitudes to supply of take-home naloxone among people with chronic noncancer pain prescribed opioids. Pain Medicine, 19(3), 533-540. https://doi.org/10.1093/pm/pnx021
  6. 6.Roxburgh, A., Hall, W. D., Dobbins, T., Gisev, N., Burns, L., Pearson, S., & Degenhardt, L. (2017). Trends in heroin and pharmaceutical opioid overdose deaths in Australia. Drug and Alcohol Dependence, 179, 291-298. https://doi.org/10.1016/j.drugalcdep.2017.07.018
  7. 7.University of Colorado, Denver. (2024). Clinical Decision Support to Improve System Naloxone Co-prescribing. ClinicalTrials.gov. NCT06271668. https://clinicaltrials.gov/study/NCT06271668
  8. 8.Walley, A. Y., Xuan, Z., Hackman, H. H., Quinn, E., Doe-Simkins, M., Sorensen-Alawad, A., Ruiz, S., & Ozonoff, A. (2013). Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis. BMJ, 346, f174. https://doi.org/10.1136/bmj.f174
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247 Health News Editorial

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