Health Technology/clinical-trials

Can AI Outperform Clinicians on ASA Physical Status Classification? New Retrospective Trial Pits ChatGPT, DeepSeek, Gemini, and Claude Against Senior Anesthesiologists

247 Health News Editorial

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28 July 2026

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5 min read

·clinical-trials

A new retrospective trial from Marmara University will benchmark ChatGPT, DeepSeek, Gemini, and Claude against senior anesthesiologists in assigning ASA Physical Status classifications from de-identified clinical vignettes. With interrater variability in ASA-PS classification a long-standing clinical problem, the findings could have significant implications for perioperative risk assessment practice worldwide.

Originally reported by ClinicalTrials.gov

References

  1. 1.Marmara University Pendik Training and Research Hospital. (2025). Comparison of clinical assessment and large language models in preoperative risk classification: A retrospective analysis of ChatGPT, DeepSeek, Gemini, and Claude in ASA physical status classification (NCT07696221). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07696221
  2. 2.Doyle, D. J., & Garmon, E. H. (2024). American Society of Anesthesiologists classification (ASA class). In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK441940/
  3. 3.Kung, T. H., Cheatham, M., Medenilla, A., Sillos, C., De Leon, L., Elepaño, C., Madriaga, M., Aggabao, R., Diaz-Candido, G., Maningo, J., & Tseng, V. (2023). Performance of ChatGPT on USMLE: Potential for AI-assisted medical education using large language models. PLOS Digital Health, 2(2), e0000198. https://doi.org/10.1371/journal.pdig.0000198
  4. 4.Sankar, A., Johnson, S. R., Beattie, W. S., Tait, G., & Wijeysundera, D. N. (2014). Reliability of the American Society of Anesthesiologists physical status scale in clinical practice. British Journal of Anaesthesia, 113(3), 424–432. https://doi.org/10.1093/bja/aeu100
  5. 5.Hackett, N. J., De Oliveira, G. S., Jain, U. K., & Kim, J. Y. S. (2015). ASA class is a reliable independent predictor of medical complications and mortality following surgery. International Journal of Surgery, 18, 184–190. https://doi.org/10.1016/j.ijsu.2015.03.007
  6. 6.American Society of Anesthesiologists. (2020). ASA physical status classification system. https://www.asahq.org/standards-and-practice-parameters/statement-on-asa-physical-status-classification-system
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