AMUSED Trial: Multimodal Music Therapy vs Reading for Severe Dementia Behavioural Symptoms — Pilot RCT Opens
247 Health News Editorial
·27 May 2026
·4 min read
·clinical-trialsThe AMUSED pilot trial investigates whether multimodal music therapy can reduce behavioural symptoms in severe dementia residents compared to reading activities. This 45-participant RCT across Kentucky facilities tests twice-weekly group sessions over 12 weeks, addressing critical gaps in non-pharmacological dementia care.
Originally reported by ClinicalTrials.gov
References
- 1.Australian Government Department of Health. (2023). Clinical Practice Guidelines and Principles of Care for People with Dementia. Australian Government Publishing. https://www.health.gov.au/resources/publications/clinical-practice-guidelines-and-principles-of-care-for-people-with-dementia
- 2.Baird, A., & Samson, S. (2009). Memory for music in Alzheimer's disease: unforgettable? Neuropsychology Review, 19(3), 305-317. https://doi.org/10.1007/s11065-009-9108-1
- 3.Hernandez, A. E. (2024). Pilot Randomized Clinical Trial of A Multimodal Music Therapy Intervention for Engaging Persons With Severe Dementia (AMUSED). ClinicalTrials.gov. NCT06605157. https://clinicaltrials.gov/study/NCT06605157
- 4.Jacobsen, J. H., Stelzer, J., Fritz, T. H., Chételat, G., La Joie, R., & Turner, R. (2015). Why musical memory can be preserved in advanced Alzheimer's disease. Brain, 138(8), 2438-2450. https://doi.org/10.1093/brain/awv135
- 5.Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J., & DeKosky, S. (2002). Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA, 288(12), 1475-1483. https://doi.org/10.1001/jama.288.12.1475
- 6.Raglio, A., Bellelli, G., Traficante, D., Gianotti, M., Ubezio, M. C., Villani, D., & Trabucchi, M. (2008). Efficacy of music therapy in the treatment of behavioral and psychiatric symptoms of dementia. Alzheimer Disease & Associated Disorders, 22(2), 158-162. https://doi.org/10.1097/WAD.0b013e31816b9393
- 7.Saliba, D., Buchanan, J., Edelen, M. O., Streim, J., Ouslander, J., Berlowitz, D., & Chodosh, J. (2012). MDS 3.0: brief interview for mental status. Journal of the American Medical Directors Association, 13(7), 611-617. https://doi.org/10.1016/j.jamda.2012.06.004
- 8.Schneider, L. S., Dagerman, K. S., & Insel, P. (2005). Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA, 294(15), 1934-1943. https://doi.org/10.1001/jama.294.15.1934
- 9.Särkämö, T., Tervaniemi, M., Laitinen, S., Numminen, A., Kurki, M., Johnson, J. K., & Rantanen, P. (2014). Cognitive, emotional, and social benefits of regular musical activities in early dementia: randomized controlled study. The Gerontologist, 54(4), 634-650. https://doi.org/10.1093/geront/gnt100
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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